Epigenetics & Nuclear Signaling Antibodies 4

Anti-SMYD1 Antibody (CAB7308)

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SKU:
CAB7308
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SMYD1 Antibody
Antibody SKU:CAB7308
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human SMYD1 (NP_938015.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Raji, MCF7, Mouse skeletal muscle, Rat heart, Rat skeletal muscle
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human SMYD1 (NP_938015.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTIG RMEN VEVF TAEG KGRG LKAT KEFW AADI IFAE RAYS AVVF DSLV NFVC HTCF KRQE KLHR CGQC KFAH YCDR TCQK DAWL NHKN ECSA IKRY GKVP NENI RLAA RIMW RVER EGTG LTEG CLVS VDDL QNHV EHFG EEEQ KDLR VDVD TFLQ YWPP QSQQ FSMQ YISH IFGV INCN GFTL SDQR GLQA VGVG IFPN LGLV NHDC WPNC TVIF NNGN HEAV KSMF HTQM RIEL RALG KISE GEEL TVSY IDFL NVSE ERKR QLKK QYYF DCTC EHCQ KKLK DDLF LGVK DNPK PSQE VVKE MIQF SKDT LEKI DKAR SEGL YHEV VKLC RECL EKQE PVFA DTNI YM
Gene ID:150572
Uniprot:Q8NB12
Cellular Location:Cytoplasm, Nucleus
Calculated MW:56kDa
Observed MW:54kDa
Synonyms:SMYD1, BOP, KMT3D, ZMYND18, ZMYND22
Background:
UniProt Protein Function:SMYD1: Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
UniProt Protein Details:

Protein type:Methyltransferase, protein lysine; Transcription, coactivator/corepressor; EC 2.1.1.43

Chromosomal Location of Human Ortholog: 2p11.2

Cellular Component: cytoplasm; nucleus

Molecular Function:protein binding; DNA binding; metal ion binding; histone-lysine N-methyltransferase activity; transcription corepressor activity

Biological Process: chromatin remodeling; transcription, DNA-dependent; heart development; negative regulation of transcription, DNA-dependent; positive regulation of myoblast differentiation

UniProt Code:Q8NB12
NCBI GenInfo Identifier:34925329
NCBI Gene ID:150572
NCBI Accession:Q8NB12.1
UniProt Secondary Accession:Q8NB12,A0AV30, A6NE13,
UniProt Related Accession:Q8NB12
Molecular Weight:490
NCBI Full Name:Histone-lysine N-methyltransferase SMYD1
NCBI Synonym Full Names:SET and MYND domain containing 1
NCBI Official Symbol:SMYD1  
NCBI Official Synonym Symbols:BOP; KMT3D; ZMYND18; ZMYND22  
NCBI Protein Information:histone-lysine N-methyltransferase SMYD1; CD8 beta opposite; zinc finger, MYND domain containing 18; SET and MYND domain-containing protein 1
UniProt Protein Name:Histone-lysine N-methyltransferase SMYD1
UniProt Synonym Protein Names:SET and MYND domain-containing protein 1
Protein Family:Histone-lysine N-methyltransferase
UniProt Gene Name:SMYD1  
UniProt Entry Name:SMYD1_HUMAN
Anti-SMYD1 Antibody (CAB7308)Western blot analysis of extracts of various cell lines, using SMYD1 antibody (CAB7308) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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