Cell Death Antibodies 1
Anti-SMNDC1 Antibody (CAB0681)
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- SKU:
- CAB0681
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-SMNDC1 Antibody |
| Antibody SKU: | CAB0681 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human SMNDC1 (NP_005862.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, HT-1080, PC-12, SH-SY5Y, SKOV3, Mouse thymus, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human SMNDC1 (NP_005862.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSED LAKQ LASY KAQL QQVE AALS GNGE NEDL LKLK KDLQ EVIE LTKD LLST QPSE TLAS SDSF ASTQ PTHS WKVG DKCM AVWS EDGQ CYEA EIEE IDEE NGTA AITF AGYG NAEV TPLL NLKP VEEG RKAK EDSG NKPM SKKE MIAQ QREY KKKK ALKK AQRI KELE QERE DQKV KWQQ FNNR AYSK NKKG QVKR SIFA SPES VTGK VGVG TCGI ADKP MTQY QDTS KYNV RHLM PQ |
| Gene ID: | 10285 |
| Uniprot: | O75940 |
| Cellular Location: | Cajal body, Nucleus, Nucleus speckle |
| Calculated MW: | 26kDa |
| Observed MW: | 27kDa |
| Synonyms: | SMNDC1, SMNR, SPF30, TDRD16C |
| Background: | This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. |
| UniProt Protein Function: | SPF30: Necessary for spliceosome assembly. Overexpression causes apoptosis. Belongs to the SMN family. |
| UniProt Protein Details: | Protein type:Spliceosome; RNA processing; RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: 10q23 Cellular Component: nucleoplasm; spliceosome; Cajal body; intermediate filament cytoskeleton; cytoplasm; nuclear speck; nucleus Molecular Function:protein binding Biological Process: RNA splicing, via transesterification reactions; apoptosis; RNA splicing; spliceosome assembly; mRNA processing |
| NCBI Summary: | This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75940 |
| NCBI GenInfo Identifier: | 37087924 |
| NCBI Gene ID: | 10285 |
| NCBI Accession: | O75940.1 |
| UniProt Related Accession: | O75940 |
| Molecular Weight: | |
| NCBI Full Name: | Survival of motor neuron-related-splicing factor 30 |
| NCBI Synonym Full Names: | survival motor neuron domain containing 1 |
| NCBI Official Symbol: | SMNDC1 |
| NCBI Official Synonym Symbols: | SMNR; SPF30; TDRD16C |
| NCBI Protein Information: | survival of motor neuron-related-splicing factor 30 |
| UniProt Protein Name: | Survival of motor neuron-related-splicing factor 30 |
| UniProt Synonym Protein Names: | 30 kDa splicing factor SMNrp; SMN-related protein; Survival motor neuron domain-containing protein 1 |
| Protein Family: | Survival of motor neuron-related-splicing factor |
| UniProt Gene Name: | SMNDC1 |
| UniProt Entry Name: | SPF30_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SMNDC1 antibody (CAB0681) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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