Cell Biology Antibodies 14
Anti-SMG5 Antibody (CAB18123)
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- SKU:
- CAB18123
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SMG5 Antibody |
| Antibody SKU: | CAB18123 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SMG5. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human SMG5. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23381 |
| Uniprot: | Q9UPR3 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | EST1B, LPTS-RP1, LPTSRP1, SMG-5, SMG5 |
| Background: |
| UniProt Protein Function: | SMG5: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q21.2 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:histone deacetylase binding; protein binding; protein phosphatase 2A binding; telomeric DNA binding; ubiquitin protein ligase binding Biological Process: mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; regulation of dephosphorylation; regulation of telomere maintenance; regulation of telomere maintenance via telomerase |
| NCBI Summary: | SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9UPR3 |
| NCBI GenInfo Identifier: | 84029494 |
| NCBI Gene ID: | 23381 |
| NCBI Accession: | Q9UPR3.3 |
| UniProt Secondary Accession: | Q9UPR3,Q5QJE7, Q659C7, Q8IXC0, Q8IY09, Q96IJ7, D3DVB7 |
| UniProt Related Accession: | Q9UPR3 |
| Molecular Weight: | 113,928 Da |
| NCBI Full Name: | Protein SMG5 |
| NCBI Synonym Full Names: | SMG5, nonsense mediated mRNA decay factor |
| NCBI Official Symbol: | SMG5 |
| NCBI Official Synonym Symbols: | EST1B; SMG-5; LPTSRP1; LPTS-RP1 |
| NCBI Protein Information: | protein SMG5 |
| UniProt Protein Name: | Protein SMG5 |
| UniProt Synonym Protein Names: | EST1-like protein B; LPTS-RP1; LPTS-interacting protein; SMG-5 homolog; hSMG-5 |
| Protein Family: | Protein |
| UniProt Gene Name: | SMG5 |
| UniProt Entry Name: | SMG5_HUMAN |
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