UniProt Protein Function: | SMCP: Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: cytoplasm; mitochondrion Molecular Function:protein binding Biological Process: penetration of zona pellucida; sperm motility |
NCBI Summary: | Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49901 |
NCBI GenInfo Identifier: | 20141463 |
NCBI Gene ID: | 4184 |
NCBI Accession: | P49901.2 |
UniProt Secondary Accession: | P49901,Q96A42, |
UniProt Related Accession: | P49901 |
Molecular Weight: | 12,767 Da |
NCBI Full Name: | Sperm mitochondrial-associated cysteine-rich protein |
NCBI Synonym Full Names: | sperm mitochondria associated cysteine rich protein |
NCBI Official Symbol: | SMCP |
NCBI Official Synonym Symbols: | MCS; MCSP; HSMCSGEN1 |
NCBI Protein Information: | sperm mitochondrial-associated cysteine-rich protein |
UniProt Protein Name: | Sperm mitochondrial-associated cysteine-rich protein |
Protein Family: | Sperm mitochondrial-associated cysteine-rich protein |
UniProt Gene Name: | SMCP |
UniProt Entry Name: | MCSP_HUMAN |