Cell Cycle Antibodies 1
Anti-SMC4 Antibody (CAB13933)
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- SKU:
- CAB13933
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-SMC4 Antibody |
| Antibody SKU: | CAB13933 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMC4 (NP_001275682.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29, MCF7, Raji, HeLa |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMC4 (NP_001275682.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPRK GTQP STAR RREE GPPP PSPD GASS DAEP EPPS GRTE SPAT AAAM TNEA GAPR LMIT HIVN QNFK SYAG EKIL GPFH KRFS CIIG PNGS GKSN VIDS |
| Gene ID: | 10051 |
| Uniprot: | Q9NTJ3 |
| Cellular Location: | Chromosome, Cytoplasm, Nucleus |
| Calculated MW: | 140kDa/147kDa |
| Observed MW: | 147kDa |
| Synonyms: | SMC4, CAP-C, CAPC, SMC-4, SMC4L1, hCAP-C |
| Background: | This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. |
| UniProt Protein Function: | SMC4: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Widely expressed. Higher expression in testis, colon, thymus. Belongs to the SMC family. SMC4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 3q26.1 Cellular Component: nucleoplasm; cytoplasm; condensin complex; cytosol; nucleus Molecular Function:protein binding; protein heterodimerization activity; ATP binding Biological Process: mitotic sister chromatid segregation; meiotic chromosome condensation; mitotic chromosome condensation; cell division; mitotic cell cycle; kinetochore organization and biogenesis; meiotic chromosome segregation |
| NCBI Summary: | This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016] |
| UniProt Code: | Q9NTJ3 |
| NCBI GenInfo Identifier: | 50658065 |
| NCBI Gene ID: | 10051 |
| NCBI Accession: | NP_005487.3 |
| UniProt Related Accession: | Q9NTJ3 |
| Molecular Weight: | Observed: 150 kDaPredicted: 148 kDa |
| NCBI Full Name: | structural maintenance of chromosomes protein 4 isoform 1 |
| NCBI Synonym Full Names: | structural maintenance of chromosomes 4 |
| NCBI Official Symbol: | SMC4 |
| NCBI Official Synonym Symbols: | CAPC; CAP-C; SMC-4; SMC4L1 |
| NCBI Protein Information: | structural maintenance of chromosomes protein 4 |
| UniProt Protein Name: | Structural maintenance of chromosomes protein 4 |
| UniProt Synonym Protein Names: | Chromosome-associated polypeptide C; hCAP-C; XCAP-C homolog |
| Protein Family: | Structural maintenance of chromosomes protein |
| UniProt Gene Name: | SMC4 |
| UniProt Entry Name: | SMC4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SMC4 antibody (CAB13933) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3s. |
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