Anti-SMC3 Antibody (CAB19591)
- SKU:
- CAB19591
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BAM
- Synonyms:
- BMH
- Synonyms:
- CDLS3
- Synonyms:
- CSPG6
- Synonyms:
- HCAP
- Synonyms:
- SMC3L1
- Research Area:
- Cell Biology
Description
| Product Name: | SMC3 Rabbit mAb |
| Product Code: | CAB19591 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SMC3 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, NIH/3T3, Jurkat, C6, U-87MG, Mouse brain, Mouse spleen |
| Immunogen: | A synthesized peptide derived from human SMC3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9126 |
| Uniprot: | Q9UQE7 |
| Calculated MW: | 141kDa |
| Observed MW: | 142KDa |
| UniProt Protein Function: | SMC3: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. Interacts with MXI1, MXD3 and MXD4. Interacts with SYCP2. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/APRIN and PDS5B/SCC-112. Forms a heterodimer with SMC1A or SMC1B in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and in chromosome movement. Interacts with PDS5A and WAPAL; regulated by SMC3 acetylation. Belongs to the SMC family. SMC3 subfamily. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; DNA repair, damage Chromosomal Location of Human Ortholog: 10q25 Cellular Component: cohesin complex; spindle pole; nuclear matrix; cohesin core heterodimer; chromosome; cytosol; nucleoplasm; lateral element; cytoplasm; basement membrane; chromatin; nucleus; chromosome, pericentric region Molecular Function:dynein binding; protein binding; protein heterodimerization activity; microtubule motor activity; chromatin binding; ATP binding Biological Process: mitosis; meiosis; mitotic spindle organization and biogenesis; cell division; mitotic sister chromatid cohesion; stem cell maintenance; sister chromatid cohesion; negative regulation of DNA endoreduplication; mitotic cell cycle; signal transduction; DNA repair; regulation of DNA replication Disease: Cornelia De Lange Syndrome 3 |
| NCBI Summary: | This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UQE7 |
| NCBI GenInfo Identifier: | 29337005 |
| NCBI Gene ID: | 9126 |
| NCBI Accession: | Q9UQE7.2 |
| UniProt Related Accession: | Q9UQE7 |
| Molecular Weight: | |
| NCBI Full Name: | Structural maintenance of chromosomes protein 3 |
| NCBI Synonym Full Names: | structural maintenance of chromosomes 3 |
| NCBI Official Symbol: | SMC3 |
| NCBI Official Synonym Symbols: | BAM; BMH; HCAP; CDLS3; CSPG6; SMC3L1 |
| NCBI Protein Information: | structural maintenance of chromosomes protein 3 |
| UniProt Protein Name: | Structural maintenance of chromosomes protein 3 |
| UniProt Synonym Protein Names: | Basement membrane-associated chondroitin proteoglycan; Bamacan; Chondroitin sulfate proteoglycan 6; Chromosome-associated polypeptide; hCAP |
| Protein Family: | Protein bag-of-marbles |
| UniProt Gene Name: | SMC3 |
| UniProt Entry Name: | SMC3_HUMAN |
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