Cell Cycle Antibodies 1
Anti-SMC1B Antibody (CAB12905)
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- SKU:
- CAB12905
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-SMC1B Antibody |
| Antibody SKU: | CAB12905 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1012-1161 of human SMC1B (NP_001278430.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Rat |
| Positive Samples: | Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1012-1161 of human SMC1B (NP_001278430.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ILLK TAAP NLRA LENL KTVR DKFQ ESTD AFEA SRKE ARLC RQEF EQVK KRRY DLFT QCFE HVSI SIDQ IYKK LCRN NSAQ VSSY IKEQ TQDQ FQMI VISL KEEF YSRA DALI GIYP EYDD CMFS RVLT LDLS QYPD TEGQ ESSK RHGE SR |
| Gene ID: | 27127 |
| Uniprot: | Q8NDV3 |
| Cellular Location: | Chromosome, Nucleus, centromere |
| Calculated MW: | 135kDa/143kDa |
| Observed MW: | 144kDa |
| Synonyms: | SMC1B, SMC1BETA, SMC1L2 |
| Background: |
| UniProt Protein Function: | SMC1B: Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Belongs to the SMC family. SMC1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 22q13.31 Cellular Component: cytoplasm; nucleoplasm |
| NCBI Summary: | SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8NDV3 |
| NCBI GenInfo Identifier: | 57015410 |
| NCBI Gene ID: | 27127 |
| NCBI Accession: | Q8NDV3.2 |
| UniProt Secondary Accession: | Q8NDV3,Q5TIC3, Q6ZUF9, Q9Y3G5, A0AV46, B0QY23, B0QY24 |
| UniProt Related Accession: | Q8NDV3 |
| Molecular Weight: | 143,837 Da |
| NCBI Full Name: | Structural maintenance of chromosomes protein 1B |
| NCBI Synonym Full Names: | structural maintenance of chromosomes 1B |
| NCBI Official Symbol: | SMC1B |
| NCBI Official Synonym Symbols: | SMC1L2; SMC1BETA |
| NCBI Protein Information: | structural maintenance of chromosomes protein 1B |
| UniProt Protein Name: | Structural maintenance of chromosomes protein 1B |
| Protein Family: | Structural maintenance of chromosomes protein |
| UniProt Gene Name: | SMC1B |
| UniProt Entry Name: | SMC1B_HUMAN |
 | Western blot analysis of extracts of rat testis, using SMC1B antibody (CAB12905) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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