Anti-SMARCD3 Antibody (CAB20174)
- SKU:
- CAB20174
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- Rsc6p
- Synonyms:
- BAF60C
- Synonyms:
- CRACD3
Description
| Product Name: | SMARCD3 Rabbit pAb |
| Product Code: | CAB20174 |
| Size: | 50uL, 100uL |
| Synonyms: | Rsc6p, BAF60C, CRACD3 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SMARCD3. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, PC-3, Mouse heart, Rat heart |
| Immunogen: | Recombinant protein of human SMARCD3. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6604 |
| Uniprot: | Q6STE5 |
| Calculated MW: | 55kDa |
| Observed MW: | 58KDa |
| UniProt Protein Function: | SMARCD3: Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Belongs to the SMARCD family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 7q35-q36 Cellular Component: nucleoplasm; SWI/SNF complex; cytoplasm; nuclear chromatin; nucleus Molecular Function:ligand-dependent nuclear receptor binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity; transcription factor binding; receptor binding; nuclear hormone receptor binding Biological Process: regulation of transcription from RNA polymerase II promoter; chromatin remodeling; positive regulation of neuroblast proliferation; muscle cell differentiation; nucleosome disassembly; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of protein binding; cellular lipid metabolic process |
| NCBI Summary: | The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6STE5 |
| NCBI GenInfo Identifier: | 57013057 |
| NCBI Gene ID: | 6604 |
| NCBI Accession: | Q6STE5.1 |
| UniProt Secondary Accession: | Q6STE5,Q2YD86, Q75MJ2, Q75MR8, Q92926, Q9BUH1, D3DX10 |
| UniProt Related Accession: | Q6STE5 |
| Molecular Weight: | 483 |
| NCBI Full Name: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 |
| NCBI Synonym Full Names: | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
| NCBI Official Symbol: | SMARCD3 |
| NCBI Official Synonym Symbols: | Rsc6p; BAF60C; CRACD3 |
| NCBI Protein Information: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Swp73-like protein; BRG1-associated factor 60C; SWI/SNF complex 60 kDa subunit C; chromatin remodeling complex BAF60C subunit; 60 kDa BRG-1/Brm-associated facto |
| UniProt Protein Name: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 |
| UniProt Synonym Protein Names: | 60 kDa BRG-1/Brm-associated factor subunit C; BRG1-associated factor 60C; BAF60C |
| Protein Family: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily |
| UniProt Gene Name: | SMARCD3 |
| UniProt Entry Name: | SMRD3_HUMAN |
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