Anti-SMARCD3 Antibody (CAB20174)

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SKU:
CAB20174

Description

Product Name:SMARCD3 Rabbit pAb
Product Code:CAB20174
Size:50uL, 100uL
Synonyms:Rsc6p, BAF60C, CRACD3
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human SMARCD3.
Applications:WB
Recommended Dilutions:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, PC-3, Mouse heart, Rat heart
Immunogen:Recombinant protein of human SMARCD3.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6604
Uniprot:Q6STE5
Calculated MW:55kDa
Observed MW:58KDa
UniProt Protein Function:SMARCD3: Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Belongs to the SMARCD family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 7q35-q36

Cellular Component: nucleoplasm; SWI/SNF complex; cytoplasm; nuclear chromatin; nucleus

Molecular Function:ligand-dependent nuclear receptor binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity; transcription factor binding; receptor binding; nuclear hormone receptor binding

Biological Process: regulation of transcription from RNA polymerase II promoter; chromatin remodeling; positive regulation of neuroblast proliferation; muscle cell differentiation; nucleosome disassembly; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of protein binding; cellular lipid metabolic process

NCBI Summary:The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q6STE5
NCBI GenInfo Identifier:57013057
NCBI Gene ID:6604
NCBI Accession:Q6STE5.1
UniProt Secondary Accession:Q6STE5,Q2YD86, Q75MJ2, Q75MR8, Q92926, Q9BUH1, D3DX10
UniProt Related Accession:Q6STE5
Molecular Weight:483
NCBI Full Name:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
NCBI Synonym Full Names:SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
NCBI Official Symbol:SMARCD3  
NCBI Official Synonym Symbols:Rsc6p; BAF60C; CRACD3  
NCBI Protein Information:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Swp73-like protein; BRG1-associated factor 60C; SWI/SNF complex 60 kDa subunit C; chromatin remodeling complex BAF60C subunit; 60 kDa BRG-1/Brm-associated facto
UniProt Protein Name:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
UniProt Synonym Protein Names:60 kDa BRG-1/Brm-associated factor subunit C; BRG1-associated factor 60C; BAF60C
Protein Family:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily
UniProt Gene Name:SMARCD3  
UniProt Entry Name:SMRD3_HUMAN
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Additional Information

Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
Rsc6p
Synonyms:
BAF60C
Synonyms:
CRACD3
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