Epigenetics & Nuclear Signaling Antibodies 1
Anti-SMARCA1 Antibody (CAB10248)
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- SKU:
- CAB10248
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-SMARCA1 Antibody |
| Antibody SKU: | CAB10248 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SMARCA1 (NP_003060.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, A-549, HT-1080, LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SMARCA1 (NP_003060.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEQD TAAV AATV AAAD ATAT IVVI EDEQ PGPS TSQE EGAA AAAT EATA ATEK GEKK KEKN VSSF QLKL AAKA PKSE KEMD PEYE EKMK ADRA KRFE FLLK QTEL FAHF IQPS AQKS PTSP LNMK LGRP RIKK DEKQ SLIS AGDY RHRR TEQE EDEE LLSE SRKT SNVC IRFE VSPS YVKG GPLR DYQI RGLN WLIS LYEN |
| Gene ID: | 6594 |
| Uniprot: | P28370 |
| Cellular Location: | Nucleus |
| Calculated MW: | 121kDa/122kDa |
| Observed MW: | 140kDa |
| Synonyms: | SMARCA1, ISWI, NURF140, SNF2L, SNF2L1, SNF2LB, SNF2LT, SWI, SWI2, hSNF2L |
| Background: | This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SMARCA1: Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. Part of the nucleosome-remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Part of the CECR2-containing-remodeling factor (CERF) complex which contains CECR2 and SMARCA1. Interacts with PRLR. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Transcription regulation Chromosomal Location of Human Ortholog: Xq25-q26.1 Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:DNA-dependent ATPase activity; protein binding; transcription factor binding Biological Process: ATP-dependent chromatin remodeling; brain development; chromatin remodeling; neuron differentiation; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | P28370 |
| NCBI GenInfo Identifier: | 115311627 |
| NCBI Gene ID: | 6594 |
| NCBI Accession: | P28370.2 |
| UniProt Secondary Accession: | P28370,Q5JV41, Q5JV42, |
| UniProt Related Accession: | P28370 |
| Molecular Weight: | 123kDa |
| NCBI Full Name: | Probable global transcription activator SNF2L1 |
| NCBI Synonym Full Names: | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 |
| NCBI Official Symbol: | SMARCA1 |
| NCBI Official Synonym Symbols: | SWI; ISWI; SWI2; SNF2L; SNF2L1; SNF2LB; SNF2LT; hSNF2L; NURF140 |
| NCBI Protein Information: | probable global transcription activator SNF2L1 |
| UniProt Protein Name: | Probable global transcription activator SNF2L1 |
| UniProt Synonym Protein Names: | ATP-dependent helicase SMARCA1; Nucleosome-remodeling factor subunit SNF2L; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 |
| Protein Family: | Probable global transcription activator |
| UniProt Gene Name: | SMARCA1 |
 | Western blot analysis of extracts of various cell lines, using SMARCA1 antibody (CAB10248) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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