ChIP Antibodies

Anti-SLURP1 Antibody (CAB7123)

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SKU:
CAB7123
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SLURP1 Antibody
Antibody SKU:CAB7123
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-103 of human SLURP1 (NP_065160.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-103 of human SLURP1 (NP_065160.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASR WAVQ LLLV AAWS MGCG EALK CYTC KEPM TSAS CRTI TRCK PEDT ACMT TLVT VEAE YPFN QSPV VTRS CSSS CVAT DPDS IGAA HLIF CCFR DLCN SEL
Gene ID:57152
Uniprot:P55000
Cellular Location:Secreted
Calculated MW:11kDa
Observed MW:11kDa
Synonyms:SLURP1, ANUP, ARS, ArsB, LY6LS, MDM
Background:The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.
UniProt Protein Function:SLURP1: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. Defects in SLURP1 are a cause of Mal de Meleda (MDM); also known as keratosis palmoplantaris transgradiens of Siemens. MDM is a rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: extracellular space; extracellular region

Molecular Function:cytokine activity

Biological Process: cell activation; neuromuscular process controlling posture; locomotory behavior; cell adhesion

Disease: Mal De Meleda

NCBI Summary:The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
UniProt Code:P55000
NCBI GenInfo Identifier:3287957
NCBI Gene ID:57152
NCBI Accession:P55000.2
UniProt Secondary Accession:P55000,Q53YJ6, Q6PUA6, Q92483,
UniProt Related Accession:P55000
Molecular Weight:11kDa
NCBI Full Name:Secreted Ly-6/uPAR-related protein 1
NCBI Synonym Full Names:secreted LY6/PLAUR domain containing 1
NCBI Official Symbol:SLURP1  
NCBI Official Synonym Symbols:ARS; MDM; ANUP; ArsB; LY6LS  
NCBI Protein Information:secreted Ly-6/uPAR-related protein 1; SLURP-1; ARS(component B)-81/S; anti-neoplastic urinary protein; lymphocyte antigen 6-like secreted; secreted Ly6/uPAR related protein 1
UniProt Protein Name:Secreted Ly-6/uPAR-related protein 1
UniProt Synonym Protein Names:ARS component B; ARS(component B)-81/S; Anti-neoplastic urinary protein; ANUP
Protein Family:Secreted Ly-6/uPAR-related protein
UniProt Gene Name:SLURP1  
UniProt Entry Name:SLUR1_HUMAN
Anti-SLURP1 Antibody (CAB7123)Western blot analysis of extracts of mouse heart, using SLURP1 antibody (CAB7123) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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