Cell Death Antibodies 2
Anti-SLK Antibody (CAB7213)
- SKU:
- CAB7213
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-SLK Antibody |
| Antibody SKU: | CAB7213 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human SLK (NP_055535.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, HeLa, Mouse liver, Mouse heart, Mouse lung, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human SLK (NP_055535.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSFF NFRK IFKL GSEK KKKQ YEHV KRDL NPED FWEI IGEL GDGA FGKV YKAQ NKET SVLA AAKV IDTK SEEE LEDY MVEI DILA SCDH PNIV KLLD AFYY ENNL WILI EFCA GGAV DAVM LELE RPLT ESQI QVVC KQTL DALN YLHD NKII HRDL KAGN ILFT LDGD IKLA DFGV SAKN TRTI QRRD SFIG TPYW MAPE VVMC ETSK DRPY DYKA DVWS LGIT LIEM AE |
| Gene ID: | 9748 |
| Uniprot: | Q9H2G2 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 138kDa/142kDa |
| Observed MW: | 250kDa |
| Synonyms: | SLK, LOSK, STK2, bA16H23.1, se20-9 |
| Background: |
| UniProt Protein Function: | SLK: a microtubule-associated protein kinase required for progression through G2. Co-localizes with the mitotic spindle in cells undergoing mitosis. Regulates actin reorganization during cell adhesion and spreading via a Rac1-mediated pathway. Signals via ASK1 and p38 to promote apoptosis. Activated in response to anoxia and ischemia-reperfusion injury in cell culture. It inhibits the protective aspects of the endoplasmic reticulum stress response, thus contributing to its proapoptotic effect. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; SLK subfamily Chromosomal Location of Human Ortholog: 10q24.33 Cellular Component: cytoplasm Molecular Function:protein serine/threonine kinase activity; identical protein binding; protein homodimerization activity; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: apoptosis; protein amino acid autophosphorylation |
| UniProt Code: | Q9H2G2 |
| NCBI GenInfo Identifier: | 74762732 |
| NCBI Gene ID: | 9748 |
| NCBI Accession: | Q9H2G2.1 |
| UniProt Secondary Accession: | Q9H2G2,O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0 Q9NQL1, D3DRA0, D3DRA1, |
| UniProt Related Accession: | Q9H2G2 |
| Molecular Weight: | 1235 |
| NCBI Full Name: | STE20-like serine/threonine-protein kinase |
| NCBI Synonym Full Names: | STE20-like kinase |
| NCBI Official Symbol: | SLK |
| NCBI Official Synonym Symbols: | LOSK; STK2; se20-9; bA16H23.1 |
| NCBI Protein Information: | STE20-like serine/threonine-protein kinase; hSLK; STE20-related kinase; Long Ste20-like Kinase; CTCL tumor antigen se20-9; serine/threonine-protein kinase 2; Ste20-related serine/threonine kinase; SNF1 sucrose nonfermenting like kinase; STE20-related serine/threonine-protein kinase; SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase |
| UniProt Protein Name: | STE20-like serine/threonine-protein kinase |
| UniProt Synonym Protein Names: | CTCL tumor antigen se20-9; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2 |
| Protein Family: | STE20-like serine/threonine-protein kinase |
| UniProt Gene Name: | SLK |
| UniProt Entry Name: | SLK_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLK antibody (CAB7213) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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