Cell Biology Antibodies 8

Anti-SLITRK6 Antibody (CAB3521)

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SKU:
CAB3521
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SLITRK6 Antibody
Antibody SKU:CAB3521
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 621-816 of human SLITRK6 (NP_115605.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 621-816 of human SLITRK6 (NP_115605.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IVFC AAGI VVLV LHRR RRYK KKQV DEQM RDNS PVHL QYSM YGHK TTHH TTER PSAS LYEQ HMVS PMVH VYRS PSFG PKHL EEEE ERNE KEGS DAKH LQRS LLEQ ENHS PLTG SNMK YKTT NQST EFLS FQDA SSLY RNIL EKER ELQQ LGIT EYLR KNIA QLQP DMEA HYPG AHEE LKLM ETLM YSRP RKVL VEQT
Gene ID:84189
Uniprot:Q9H5Y7
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:95kDa
Observed MW:120kDa
Synonyms:SLITRK6, DFNMYP
Background:This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness.
UniProt Protein Function:SLITRK6: Suppresses neurite outgrowth. Belongs to the SLITRK family.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q31.1

Cellular Component: cell surface; integral to plasma membrane

Biological Process: lens development in camera-type eye; vestibulocochlear nerve development; sensory perception of sound; synaptogenesis; startle response; axonogenesis; visual perception; adult locomotory behavior; multicellular organism growth; auditory receptor cell morphogenesis; auditory behavior; linear vestibuloocular reflex

Disease: Deafness And Myopia

NCBI Summary:This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. [provided by RefSeq, Dec 2014]
UniProt Code:Q9H5Y7
NCBI GenInfo Identifier:59803110
NCBI Gene ID:84189
NCBI Accession:Q9H5Y7.3
UniProt Secondary Accession:Q9H5Y7,Q495Q0, Q6AW93, Q9HAA8, Q9NT60, A8K9S8,
UniProt Related Accession:Q9H5Y7
Molecular Weight:
NCBI Full Name:SLIT and NTRK-like protein 6
NCBI Synonym Full Names:SLIT and NTRK-like family, member 6
NCBI Official Symbol:SLITRK6  
NCBI Official Synonym Symbols:DFNMYP  
NCBI Protein Information:SLIT and NTRK-like protein 6; 4832410J21Rik; slit and trk like gene 6
UniProt Protein Name:SLIT and NTRK-like protein 6
Protein Family:SLIT and NTRK-like protein
UniProt Gene Name:SLITRK6  
UniProt Entry Name:SLIK6_HUMAN
Anti-SLITRK6 Antibody (CAB3521)Western blot analysis of extracts of various cell lines, using SLITRK6 antibody (CAB3521) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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