Signal Transduction Antibodies 1

Anti-SLC9A8 Antibody (CAB12829)

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SKU:
CAB12829
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC9A8 Antibody
Antibody SKU:CAB12829
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 472-581 of human SLC9A8 (NP_056081.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 472-581 of human SLC9A8 (NP_056081.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RLMD IEDA KAHR RNKK DVNL SKTE KMGN TVES EHLS ELTE EEYE AHYI RRQD LKGF VWLD AKYL NPFF TRRL TQED LHHG RIQM KTLT NKWY EEVR QGPS GSED DEQE LL
Gene ID:23315
Uniprot:Q9Y2E8
Cellular Location:Golgi apparatus membrane, Multi-pass membrane protein
Calculated MW:65kDa/67kDa
Observed MW:65kDa
Synonyms:SLC9A8, NHE-8, NHE8
Background:
UniProt Protein Function:NHE8: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: Golgi membrane; integral to membrane

Molecular Function:potassium:hydrogen antiporter activity; sodium:hydrogen antiporter activity

Biological Process: ion transport; regulation of intracellular pH; transmembrane transport

NCBI Summary:Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]
UniProt Code:Q9Y2E8
NCBI GenInfo Identifier:254763448
NCBI Gene ID:23315
NCBI Accession:Q9Y2E8.4
UniProt Secondary Accession:Q9Y2E8,Q2M1U9, Q68CZ8, Q9BX15, Q9Y507, B4DTQ8,
UniProt Related Accession:Q9Y2E8
Molecular Weight:67,275 Da
NCBI Full Name:Sodium/hydrogen exchanger 8
NCBI Synonym Full Names:solute carrier family 9 member A8
NCBI Official Symbol:SLC9A8  
NCBI Official Synonym Symbols:NHE8; NHE-8  
NCBI Protein Information:sodium/hydrogen exchanger 8
UniProt Protein Name:Sodium/hydrogen exchanger 8
UniProt Synonym Protein Names:Na(+)/H(+) exchanger 8; NHE-8; Solute carrier family 9 member 8
UniProt Gene Name:SLC9A8  
UniProt Entry Name:SL9A8_HUMAN
Anti-SLC9A8 Antibody (CAB12829)Western blot analysis of extracts of 293T cells, using SLC9A8 antibody (CAB12829) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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