Metabolism Antibodies 1

Anti-SLC9A3R1 Antibody (CAB0146)

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SKU:
CAB0146
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-SLC9A3R1 Antibody
Antibody SKU:CAB0146
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 189-358 of human SLC9A3R1 (NP_004243.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:4000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, 293T, HT-29, MCF7, Mouse liver, Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 189-358 of human SLC9A3R1 (NP_004243.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EASG LRAQ DRIV EVNG VCME GKQH GDVV SAIR AGGD ETKL LVVD RETD EFFK KCRV IPSQ EHLN GPLP VPFT NGEI QKEN SREA LAEA ALES PRPA LVRS ASSD TSEE LNSQ DSPP KQDS TAPS STSS SDPI LDFN ISLA MAKE RAHQ KRSS KRAP QMDW SKKN ELFS NL
Gene ID:9368
Uniprot:O14745
Cellular Location:Apical cell membrane, Cell projection, Cytoplasm, Endomembrane system, Peripheral membrane protein, filopodium, microvillus, ruffle
Calculated MW:22kDa/38kDa
Observed MW:50kDa
Synonyms:SLC9A3R1, EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2
Background:This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.
NCBI Summary:This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]
UniProt Code:O14745
NCBI GenInfo Identifier:4759140
NCBI Gene ID:9368
NCBI Accession:NP_004243.1
UniProt Secondary Accession:O14745,Q9JJ19,
UniProt Related Accession:O14745
Molecular Weight:50kDa
NCBI Full Name:Na(+)/H(+) exchange regulatory cofactor NHE-RF1
NCBI Synonym Full Names:SLC9A3 regulator 1
NCBI Official Symbol:SLC9A3R1  
NCBI Official Synonym Symbols:EBP50; NHERF; NHERF1; NHERF-1; NPHLOP2  
NCBI Protein Information:Na(+)/H(+) exchange regulatory cofactor NHE-RF1
UniProt Protein Name:Na(+)/H(+) exchange regulatory cofactor NHE-RF1
UniProt Synonym Protein Names:Ezrin-radixin-moesin-binding phosphoprotein 50; EBP50; Regulatory cofactor of Na(+)/H(+) exchanger; Sodium-hydrogen exchanger regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1
UniProt Gene Name:SLC9A3R1  
UniProt Entry Name:NHRF1_HUMAN
Anti-SLC9A3R1 Antibody (CAB0146)Western blot analysis of extracts of various cell lines, using SLC9A3R1 antibody (CAB0146) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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