Cell Biology Antibodies 13
Anti-SLC9A3 Antibody (CAB17532)
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- SKU:
- CAB17532
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SLC9A3 Antibody |
| Antibody SKU: | CAB17532 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 460-600 of human SLC9A3 (NP_004165.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 460-600 of human SLC9A3 (NP_004165.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VQWL KVKR SEHR EPRL NEKL HGRA FDHI LSAI EDIS GQIG HNYL RDKW SHFD RKFL SRVL MRRS AQKS RDRI LNVF HELN LKDA ISYV AEGE RRGS LAFI RSPS TDNV VNVD FTPR SSTV EASV SYLL RENV SAVC LDMQ S |
| Gene ID: | 6550 |
| Uniprot: | P48764 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 100kDa |
 | Western blot - SLC9A3 Polyclonal Antibody (CAB17532) |
| Synonyms: | DIAR8, NHE-3, NHE3, SLC9A3 |
| Background: | The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016] |
| UniProt Protein Function: | NHE3: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Binds SLC9A3R1 and SLC9A3R2. Interacts with SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral Chromosomal Location of Human Ortholog: 5p15.3 Cellular Component: cell surface; brush border membrane; apical plasma membrane; integral to membrane; plasma membrane; brush border Molecular Function:protein binding; sodium:hydrogen antiporter activity; PDZ domain binding Biological Process: regulation of pH; ion transport; transmembrane transport |
| UniProt Code: | P48764 |
| NCBI GenInfo Identifier: | 194239733 |
| NCBI Gene ID: | 6550 |
| NCBI Accession: | NP_004165.2 |
| UniProt Secondary Accession: | P48764,Q3MIW3, B7ZKR2, E9PF67, |
| UniProt Related Accession: | P48764 |
| Molecular Weight: | 91,904 Da |
| NCBI Full Name: | sodium/hydrogen exchanger 3 isoform 1 |
| NCBI Synonym Full Names: | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 |
| NCBI Official Symbol: | SLC9A3 |
| NCBI Official Synonym Symbols: | NHE3 |
| NCBI Protein Information: | sodium/hydrogen exchanger 3 |
| UniProt Protein Name: | Sodium/hydrogen exchanger 3 |
| UniProt Synonym Protein Names: | Na(+)/H(+) exchanger 3 |
| UniProt Gene Name: | SLC9A3 |
| UniProt Entry Name: | SL9A3_HUMAN |
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