Cell Biology Antibodies 18
Anti-SLC8A3 Antibody (CAB18381)
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- SKU:
- CAB18381
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SLC8A3 Antibody |
| Antibody SKU: | CAB18381 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SLC8A3. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant protein of human SLC8A3. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6547 |
| Uniprot: | P57103 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | NCX3, SLC8A3 |
| Background: |
| UniProt Protein Function: | Mediates the electrogenic exchange of Ca2+ against Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. Contributes to cellular Ca2+ homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca2+ levels due to release of Ca2+ stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca2+ from the cell during the next phase, so that cytoplasmic Ca2+ levels rapidly return to baseline. Contributes to Ca2+ transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca2+ levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca2+ efflux from mitochondria and contributes to mitochondrial Ca2+ ion homeostasis. |
| NCBI Summary: | This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013] |
| UniProt Code: | P57103 |
| NCBI GenInfo Identifier: | 34395973 |
| NCBI Gene ID: | 6547 |
| NCBI Accession: | P57103.2 |
| UniProt Secondary Accession: | P57103,Q5K3P6, Q5K3P7, Q8IUE9, Q8IUF0, Q8NFI7, Q96QG1 Q96QG2, |
| UniProt Related Accession: | P57103 |
| Molecular Weight: | 102,804 Da |
| NCBI Full Name: | Sodium/calcium exchanger 3 |
| NCBI Synonym Full Names: | solute carrier family 8 member A3 |
| NCBI Official Symbol: | SLC8A3 |
| NCBI Official Synonym Symbols: | NCX3 |
| NCBI Protein Information: | sodium/calcium exchanger 3 |
| UniProt Protein Name: | Sodium/calcium exchanger 3 |
| UniProt Synonym Protein Names: | Na(+)/Ca(2+)-exchange protein 3; Solute carrier family 8 member 3 |
| Protein Family: | Sodium/calcium exchanger |
| UniProt Gene Name: | SLC8A3 |
| UniProt Entry Name: | NAC3_HUMAN |
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