Signal Transduction Antibodies 2

Anti-SLC7A8 Antibody (CAB14861)

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SKU:
CAB14861
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC7A8 Antibody
Antibody SKU:CAB14861
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SLC7A8 (NP_036376.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, A375
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SLC7A8 (NP_036376.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LFPT CFPP ESGL RLLA AICL LLLT WVNC SSVR WATR VQDI FTAG KLLA LALI IIMG IVQI CKGE YFWL EPKN AFEN FQEP DIGL VALA FLQG SFAY GGWN F
Gene ID:23428
Uniprot:Q9UHI5
Cellular Location:Basolateral cell membrane, Cytoplasm, Multi-pass membrane protein
Calculated MW:34kDa/37kDa/48kDa/58kDa
Observed MW:58kDa
Synonyms:SLC7A8, LAT2, LPI-PC1
Background:
UniProt Protein Function:SLC7A8: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
UniProt Protein Details:

Protein type:Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: basolateral plasma membrane; cytoplasm; integral to plasma membrane; plasma membrane

Molecular Function:amino acid transmembrane transporter activity; antiporter activity; L-amino acid transmembrane transporter activity; neutral amino acid transmembrane transporter activity; organic cation transmembrane transporter activity; peptide antigen binding; protein binding; toxin transporter activity

Biological Process: amino acid metabolic process; amino acid transport; blood coagulation; ion transport; leukocyte migration; metal ion homeostasis; neutral amino acid transport; organic cation transport; response to toxin; transmembrane transport; transport

UniProt Code:Q9UHI5
NCBI GenInfo Identifier:33286428
NCBI Gene ID:23428
NCBI Accession:NP_036376
UniProt Secondary Accession:Q9UHI5,Q86U05, Q9UKQ6, Q9UKQ7, Q9UKQ8, Q9Y445, B2R8Q4 B4DKT4, B4DTV6, D3DS46, F2Z2J4,
UniProt Related Accession:Q9UHI5
Molecular Weight:48,283 Da
NCBI Full Name:large neutral amino acids transporter small subunit 2 isoform a
NCBI Synonym Full Names:solute carrier family 7 (amino acid transporter light chain, L system), member 8
NCBI Official Symbol:SLC7A8  
NCBI Official Synonym Symbols:LAT2; LPI-PC1  
NCBI Protein Information:large neutral amino acids transporter small subunit 2
UniProt Protein Name:Large neutral amino acids transporter small subunit 2
UniProt Synonym Protein Names:L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8
Protein Family:Linker for activation of T-cells family
UniProt Gene Name:SLC7A8  
UniProt Entry Name:LAT2_HUMAN
Anti-SLC7A8 Antibody (CAB14861)Western blot analysis of extracts of various cell lines, using SLC7A8 antibody (CAB14861) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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