Signal Transduction Antibodies 1
Anti-SLC7A2 Antibody (CAB14574)
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- SKU:
- CAB14574
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC7A2 Antibody |
| Antibody SKU: | CAB14574 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human SLC7A2 (NP_001008539.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HepG2, HeLa, Mouse liver, Mouse brain, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human SLC7A2 (NP_001008539.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FLAF LVLG LSVL TTYG VHAI TRLE AWSL ALLA LFLV LFVA IVLT IWRQ PQNQ QKVA FMVP FLPF LPAF SILV NIYL MVQL SADT WVRF SIWM AIGF LIYF SYGI RHSL EGHL RDEN NEED AYPD NVHA AAEE KSAI QAND HHPR NLSS PFIF HEKT SEF |
| Gene ID: | 6542 |
| Uniprot: | P52569 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 71kDa/75kDa/76kDa |
| Observed MW: | 72kDa |
| Synonyms: | SLC7A2, ATRC2, CAT2, HCAT2 |
| Background: | The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. |
| NCBI Summary: | The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P52569 |
| NCBI GenInfo Identifier: | 258614005 |
| NCBI Gene ID: | 6542 |
| NCBI Accession: | NP_001008539.3 |
| UniProt Secondary Accession: | P52569,O15291, O15292, Q14CQ6, Q6NSZ7, Q86TC6, B7ZL54 |
| UniProt Related Accession: | P52569 |
| Molecular Weight: | 75,986 Da |
| NCBI Full Name: | cationic amino acid transporter 2 isoform 2 |
| NCBI Synonym Full Names: | solute carrier family 7 member 2 |
| NCBI Official Symbol: | SLC7A2 |
| NCBI Official Synonym Symbols: | CAT2; ATRC2; HCAT2 |
| NCBI Protein Information: | cationic amino acid transporter 2 |
| UniProt Protein Name: | Cationic amino acid transporter 2 |
| UniProt Synonym Protein Names: | Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2 |
| Protein Family: | Catalase isozyme |
| UniProt Gene Name: | SLC7A2 |
 | Western blot analysis of extracts of various cell lines, using SLC7A2 antibody (CAB14574) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human mammary cancer using SLC7A2 antibody (CAB14574) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human placenta using SLC7A2 antibody (CAB14574) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat ovary using SLC7A2 antibody (CAB14574) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using SLC7A2 antibody (CAB14574) at dilution of 1:100 (40x lens). |
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