Signal Transduction Antibodies 3

Anti-SLC7A11 / xCT Antibody (CAB2413)

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SKU:
CAB2413
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SLC7A11 / xCT Antibody
Antibody SKU:CAB2413
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human SLC7A11 / xCT
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, HepG2, Rat liver, Rat brain, Mouse liver
Immunogen:A synthesized peptide derived from human SLC7A11 / xCT
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23657
Uniprot:Q9UPY5
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:55kDa
Observed MW:37KDa
Synonyms:CCBR1, xCT
Background:This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
UniProt Protein Function:Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
NCBI Summary:This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
UniProt Code:Q9UPY5
NCBI GenInfo Identifier:7657683
NCBI Gene ID:23657
NCBI Accession:NP_055146.1
UniProt Secondary Accession:Q9UPY5,A8K2U4,
UniProt Related Accession:Q9UPY5
Molecular Weight:Observed: 40 kDa-45 kDaPredicted: 56 kDa
NCBI Full Name:cystine/glutamate transporter
NCBI Synonym Full Names:solute carrier family 7 member 11
NCBI Official Symbol:SLC7A11  
NCBI Official Synonym Symbols:xCT; CCBR1  
NCBI Protein Information:cystine/glutamate transporter
UniProt Protein Name:Cystine/glutamate transporter
UniProt Synonym Protein Names:Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT
Protein Family:Protein XAP5 CIRCADIAN TIMEKEEPER
UniProt Gene Name:SLC7A11  
Anti-SLC7A11 / xCT Antibody (CAB2413)Western blot - SLC7A11 / xCT Rabbit mAb (CAB2413)
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