Signal Transduction Antibodies 1

Anti-SLC7A11 Antibody (CAB13685)

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SKU:
CAB13685
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC7A11 Antibody
Antibody SKU:CAB13685
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SLC7A11 (NP_055146.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Mouse kidney, Rat liver
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SLC7A11 (NP_055146.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ILEP FFIQ CEIP ELAI KLIT AVGI TVVM VLNS MSVS WSAR IQIF LTFC KLTA ILII IVPG VMQL IKGQ TQNF KDAF SGRD SSIT RLPL AFYY GMYA YAGW F
Gene ID:23657
Uniprot:Q9UPY5
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:55kDa
Observed MW:37kDa/55kDa
Synonyms:SLC7A11, CCBR1, xCT
Background:This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
UniProt Protein Function:Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
NCBI Summary:This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
UniProt Code:Q9UPY5
NCBI GenInfo Identifier:7657683
NCBI Gene ID:23657
NCBI Accession:NP_055146.1
UniProt Secondary Accession:Q9UPY5,A8K2U4,
UniProt Related Accession:Q9UPY5
Molecular Weight:Observed: 40 kDa-45 kDaPredicted: 56 kDa
NCBI Full Name:cystine/glutamate transporter
NCBI Synonym Full Names:solute carrier family 7 member 11
NCBI Official Symbol:SLC7A11  
NCBI Official Synonym Symbols:xCT; CCBR1  
NCBI Protein Information:cystine/glutamate transporter
UniProt Protein Name:Cystine/glutamate transporter
UniProt Synonym Protein Names:Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT
Protein Family:Protein XAP5 CIRCADIAN TIMEKEEPER
UniProt Gene Name:SLC7A11  
Anti-SLC7A11 Antibody (CAB13685)Western blot analysis of extracts of various cell lines, using SLC7A11 antibody (CAB13685) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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