Cell Biology Antibodies 13

Anti-SLC6A8 Antibody (CAB17531)

(No reviews yet) Write a Review
SKU:
CAB17531
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SLC6A8 Antibody
Antibody SKU:CAB17531
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 539-635 of human SLC6A8 (NP_005620.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, U-87MG, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 539-635 of human SLC6A8 (NP_005620.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VVYY EPLV YNNT YVYP WWGE AMGW AFAL SSML CVPL HLLG CLLR AKGT MAER WQHL TQPI WGLH HLEY RAQD ADVR GLTT LTPV SESS KVVV VESV M
Gene ID:6535
Uniprot:P48029
Cellular Location:
Calculated MW:30kDa/58kDa/70kDa/80kDa
Observed MW:65kDa
Anti-SLC6A8 Antibody (CAB17531)Western blot - SLC6A8 Polyclonal Antibody (CAB17531)
Synonyms:CCDS1, CRT, CRTR, CT1, CTR5, SLC6A8
Background:The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Protein Function:SLC6A8: Required for the uptake of creatine in muscles and brain. Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome (XL-CDS). XL-CDS causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Transporter, SLC family; Motility/polarity/chemotaxis; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function:creatine:sodium symporter activity

Biological Process: creatine metabolic process; creatine transport; muscle contraction; transport

Disease: Cerebral Creatine Deficiency Syndrome 1

NCBI Summary:The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Code:P48029
NCBI GenInfo Identifier:1352529
NCBI Gene ID:6535
NCBI Accession:P48029.1
UniProt Secondary Accession:P48029,Q13032, Q66I36, B2KY47, B4DIA3, E9PFC0,
UniProt Related Accession:P48029
Molecular Weight:58,453 Da
NCBI Full Name:Sodium- and chloride-dependent creatine transporter 1
NCBI Synonym Full Names:solute carrier family 6 member 8
NCBI Official Symbol:SLC6A8  
NCBI Official Synonym Symbols:CRT; CT1; CRTR; CTR5; CCDS1  
NCBI Protein Information:sodium- and chloride-dependent creatine transporter 1
UniProt Protein Name:Sodium- and chloride-dependent creatine transporter 1
UniProt Synonym Protein Names:Solute carrier family 6 member 8
Protein Family:Sodium- and chloride-dependent creatine transporter
UniProt Gene Name:SLC6A8  
UniProt Entry Name:SC6A8_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products