Neuroscience
Anti-SLC6A4 Antibody (CAB14171)
- SKU:
- CAB14171
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-SLC6A4 Antibody |
| Antibody SKU: | CAB14171 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human SLC6A4 (NP_001036.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, THP-1, HUVEC, Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human SLC6A4 (NP_001036.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AVLT VALI EAVA VSWF YGIT QFCR DVKE MLGF SPGW FWRI CWVA ISPL FLLF IICS FLMS PPQL RLFQ YNYP YWSI ILGY CIGT SSFI CIPT YIAY RLII TPGT FKER IIKS ITPE TPTE IPCG DIRL NAV |
| Gene ID: | 6532 |
| Uniprot: | P31645 |
| Cellular Location: | Cell membrane, Endomembrane system, Endosome membrane, Multi-pass membrane protein |
| Calculated MW: | 70kDa/74kDa |
| Observed MW: | 75KDa |
| Synonyms: | 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, SLC6A4 |
| Background: | This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. |
| UniProt Protein Function: | SERT: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; endomembrane system; endosome membrane; cytosol; lipid raft Molecular Function:actin filament binding; serotonin transmembrane transporter activity; protein binding; protein homodimerization activity; myosin binding; serotonin:sodium symporter activity; cocaine binding; syntaxin-1 binding; monoamine transmembrane transporter activity; nitric-oxide synthase binding; Rab GTPase binding Biological Process: circadian rhythm; response to drug; vasoconstriction; response to toxin; monoamine transport; positive regulation of cell cycle; social behavior; thalamus development; serotonin uptake; negative regulation of organ growth; negative regulation of synaptic transmission, dopaminergic; protein oligomerization; memory; response to estradiol stimulus; negative regulation of granule cell precursor proliferation; negative regulation of neuron differentiation; brain morphogenesis; response to hypoxia; sperm ejaculation; serotonin transport; transmembrane transport; protein homooligomerization; response to nutrient Disease: Anxiety; Obsessive-compulsive Disorder |
| NCBI Summary: | This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31645 |
| NCBI GenInfo Identifier: | 400630 |
| NCBI Gene ID: | 6532 |
| NCBI Accession: | P31645.1 |
| UniProt Secondary Accession: | P31645,Q5EE02, |
| UniProt Related Accession: | P31645,AAB26687 |
| Molecular Weight: | 74,979 Da |
| NCBI Full Name: | Sodium-dependent serotonin transporter |
| NCBI Synonym Full Names: | solute carrier family 6 (neurotransmitter transporter), member 4 |
| NCBI Official Symbol: | SLC6A4 |
| NCBI Official Synonym Symbols: | HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR |
| NCBI Protein Information: | sodium-dependent serotonin transporter; 5HT transporter; serotonin transporter 1; Na+/Cl- dependent serotonin transporter; 5-hydroxytryptamine (serotonin) transporter; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 |
| UniProt Protein Name: | Sodium-dependent serotonin transporter |
| UniProt Synonym Protein Names: | 5HT transporter; 5HTT; Solute carrier family 6 member 4 |
| UniProt Gene Name: | SLC6A4 |
| UniProt Entry Name: | SC6A4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC6A4 Polyclonal Antibody (CAB14171) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
 | Immunohistochemistry of paraffin-embedded rat testis using SLC6A4 Rabbit pAb (CAB14171) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using SLC6A4 Rabbit pAb (CAB14171) at dilution of 1:100 (40x lens). |
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