Neuroscience
Anti-SLC6A2 Antibody (CAB1421)
- SKU:
- CAB1421
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-SLC6A2 Antibody |
| Antibody SKU: | CAB1421 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human SLC6A2 (NP_001165975.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, SH-SY5Y, Mouse kidney, Mouse spinal cord |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human SLC6A2 (NP_001165975.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLLA RMNP QVQP ENNG ADTG PEQP LRAR KTAE LLVV KERN GVQC LLAP RDGD AQPR ETWG KKID FLLS VV |
| Gene ID: | 6530 |
| Uniprot: | P23975 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 57kDa/69kDa/70kDa |
| Observed MW: | 69kDa |
| Synonyms: | SLC6A2, NAT1, NET, NET1, SLC6A5 |
| Background: | This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |
| UniProt Protein Function: | SLC6A2: Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. Defects in SLC6A2 are a cause of orthostatic intolerance (OI). OI is a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 16q12.2 Cellular Component: integral to plasma membrane; membrane; neuron projection; plasma membrane Molecular Function:dopamine:sodium symporter activity; metal ion binding; monoamine transmembrane transporter activity; norephinephrine:sodium symporter activity; protein binding Biological Process: dopamine uptake; monoamine transport; norepinephrine transport; response to pain; synaptic transmission; transmembrane transport; transport Disease: Orthostatic Intolerance |
| NCBI Summary: | This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] |
| UniProt Code: | P23975 |
| NCBI GenInfo Identifier: | 128616 |
| NCBI Gene ID: | 6530 |
| NCBI Accession: | P23975.1 |
| UniProt Secondary Accession: | P23975,Q96KH8, B2R707, B4DX48, |
| UniProt Related Accession: | P23975 |
| Molecular Weight: | |
| NCBI Full Name: | Sodium-dependent noradrenaline transporter |
| NCBI Synonym Full Names: | solute carrier family 6 member 2 |
| NCBI Official Symbol: | SLC6A2 |
| NCBI Official Synonym Symbols: | NET; NAT1; NET1; SLC6A5 |
| NCBI Protein Information: | sodium-dependent noradrenaline transporter |
| UniProt Protein Name: | Sodium-dependent noradrenaline transporter |
| UniProt Synonym Protein Names: | Norepinephrine transporter; NET; Solute carrier family 6 member 2 |
| Protein Family: | Sodium-dependent noradrenaline transporter |
| UniProt Gene Name: | SLC6A2 |
| UniProt Entry Name: | SC6A2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC6A2 antibody (CAB1421) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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