Name: Anti-SLC6A15 Antibody (CAB10437)
Brand: Signal Transduction Antibodies 1
SKU: CAB10437
Availability: OutOfStock

Antibody Name:	Anti-SLC6A15 Antibody
Antibody SKU:	CAB10437
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human SLC6A15 (NP_877499.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human SLC6A15 (NP_877499.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	LVVF AVLG FKAN VINE KCIT QNSE TIMK FLKM GNIS QDII PHHI NLST VTAE DYHL VYDI IQKV KEEE FPAL HLNS CKIE EELN KAVQ GTGL AFIA FTEA M
Gene ID:	55117
Uniprot:	Q9H2J7
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	32kDa/69kDa/81kDa
Observed MW:	82kDa

Synonyms:	SLC6A15, NTT73, SBAT1, V7-3, hv7-3
Background:	This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	SLC6A15: Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 12q21.31 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:amino acid transmembrane transporter activity; proline:sodium symporter activity Biological Process: amino acid transport; leucine transport; neutral amino acid transport; proline transport
NCBI Summary:	This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Code:	Q9H2J7
NCBI GenInfo Identifier:	18202939
NCBI Gene ID:	55117
NCBI Accession:	Q9H2J7.1
UniProt Secondary Accession:	Q9H2J7,Q9H9F5, A8K592, B7Z2P7, E7ESJ5,
UniProt Related Accession:	Q9H2J7
Molecular Weight:	82kDa
NCBI Full Name:	Sodium-dependent neutral amino acid transporter B(0)AT2
NCBI Synonym Full Names:	solute carrier family 6 member 15
NCBI Official Symbol:	SLC6A15
NCBI Official Synonym Symbols:	V7-3; NTT73; SBAT1; hv7-3
NCBI Protein Information:	sodium-dependent neutral amino acid transporter B(0)AT2
UniProt Protein Name:	Sodium-dependent neutral amino acid transporter B(0)AT2
UniProt Synonym Protein Names:	Sodium- and chloride-dependent neurotransmitter transporter NTT73; Sodium-coupled branched-chain amino-acid transporter 1; Solute carrier family 6 member 15; Transporter v7-3
UniProt Gene Name:	SLC6A15

Western blot analysis of extracts of mouse kidney, using SLC6A15 antibody (CAB10437) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

SLC6A15 Antibody (PACO04686)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)