Neuroscience

Anti-SLC6A12 Antibody (CAB10378)

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SKU:
CAB10378
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Neuroscience

Description

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Antibody Name:Anti-SLC6A12 Antibody
Antibody SKU:CAB10378
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 515-614 of human SLC6A12 (NP_003035.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 515-614 of human SLC6A12 (NP_003035.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FSLS KYTP LKYN NVYV YPPW GYSI GWFL ALSS MVCV PLFV VITL LKTR GPFR KRLR QLIT PDSS LPQP KQHP CLDG SAGR NFGP SPTR EGLI AGEK ETHL
Gene ID:6539
Uniprot:P48065
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:69kDa
Observed MW:69kDa
Synonyms:SLC6A12, BGT-1, BGT1, GAT2
Background:
UniProt Protein Function:SLC6A12: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 12p13.33

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function:amino acid transmembrane transporter activity; protein binding; transporter activity

Biological Process: amino acid transport; transport

UniProt Code:P48065
NCBI GenInfo Identifier:257050987
NCBI Gene ID:6539
NCBI Accession:P48065.2
UniProt Secondary Accession:P48065,A0AV52, B2R992, D3DUN8,
UniProt Related Accession:P48065
Molecular Weight:69kDa
NCBI Full Name:Sodium- and chloride-dependent betaine transporter
NCBI Synonym Full Names:solute carrier family 6 member 12
NCBI Official Symbol:SLC6A12  
NCBI Official Synonym Symbols:BGT1; GAT2; BGT-1  
NCBI Protein Information:sodium- and chloride-dependent betaine transporter
UniProt Protein Name:Sodium- and chloride-dependent betaine transporter
UniProt Synonym Protein Names:BGT-1; Na(+)/Cl(-) betaine/GABA transporter; Solute carrier family 6 member 12
UniProt Gene Name:SLC6A12  
Anti-SLC6A12 Antibody (CAB10378)Western blot analysis of extracts of 293T cells, using SLC6A12 antibody (CAB10378) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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