Neuroscience

Anti-SLC6A11 Antibody (CAB11702)

(No reviews yet) Write a Review
SKU:
CAB11702
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Neuroscience

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SLC6A11 Antibody
Antibody SKU:CAB11702
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human SLC6A11 (NP_055044.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, LO2, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human SLC6A11 (NP_055044.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTAE KALP LGNG KAAE EARE SEAP GGGC SSGG AAPA RHPR VKRD KAVH ERGH WNNK VEFV
Gene ID:6538
Uniprot:P48066
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:23kDa/70kDa
Observed MW:62kDa
Synonyms:SLC6A11, GAT-3, GAT3, GAT4
Background:The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:SLC6A11: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function:gamma-aminobutyric acid:sodium symporter activity; transporter activity

Biological Process: transport

NCBI Summary:The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
UniProt Code:P48066
NCBI GenInfo Identifier:1352531
NCBI Gene ID:6538
NCBI Accession:P48066.1
UniProt Secondary Accession:P48066,Q8IYC9, B2R6U6,
UniProt Related Accession:P48066
Molecular Weight:71kDa
NCBI Full Name:Sodium- and chloride-dependent GABA transporter 3
NCBI Synonym Full Names:solute carrier family 6 member 11
NCBI Official Symbol:SLC6A11  
NCBI Official Synonym Symbols:GAT3; GAT4; GAT-3  
NCBI Protein Information:sodium- and chloride-dependent GABA transporter 3
UniProt Protein Name:Sodium- and chloride-dependent GABA transporter 3
UniProt Synonym Protein Names:Solute carrier family 6 member 11
Protein Family:Sodium- and chloride-dependent GABA transporter
UniProt Gene Name:SLC6A11  
Anti-SLC6A11 Antibody (CAB11702)Western blot analysis of extracts of various cell lines, using SLC6A11 antibody (CAB11702) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
View AllClose

0 Reviews

View AllClose

Related Products