Neuroscience
Anti-SLC6A1 Antibody (CAB15099)
- SKU:
- CAB15099
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-SLC6A1 Antibody |
| Antibody SKU: | CAB15099 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human SLC6A1 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse eye, Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide of human SLC6A1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6529 |
| Uniprot: | P30531 |
| Cellular Location: | Cell membrane, Membrane, Multi-pass membrane protein |
| Calculated MW: | 67kDa |
| Observed MW: | 67kDa |
| Synonyms: | SLC6A1, GABATHG, GABATR, GAT1, MAE |
| Background: | The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. |
| UniProt Protein Function: | SLC6A1: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: cell surface; membrane; integral to plasma membrane; axon; integral to membrane; plasma membrane Molecular Function:gamma-aminobutyric acid:sodium symporter activity; neurotransmitter:sodium symporter activity Biological Process: response to purine; response to toxin; neurotransmitter secretion; learning; response to cocaine; response to estradiol stimulus; response to sucrose stimulus; synaptic transmission; transport; response to lead ion; gamma-aminobutyric acid import; negative regulation of synaptic transmission, GABAergic; response to calcium ion; transmembrane transport; protein homooligomerization; positive regulation of gamma-aminobutyric acid secretion Disease: Myoclonic-atonic Epilepsy |
| NCBI Summary: | The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009] |
| UniProt Code: | P30531 |
| NCBI GenInfo Identifier: | 229462780 |
| NCBI Gene ID: | 6529 |
| NCBI Accession: | P30531.2 |
| UniProt Secondary Accession: | P30531,Q8N4K8, |
| UniProt Related Accession: | P30531 |
| Molecular Weight: | 67,074 Da |
| NCBI Full Name: | Sodium- and chloride-dependent GABA transporter 1 |
| NCBI Synonym Full Names: | solute carrier family 6 (neurotransmitter transporter), member 1 |
| NCBI Official Symbol: | SLC6A1 |
| NCBI Official Synonym Symbols: | GAT1; GABATR; GABATHG |
| NCBI Protein Information: | sodium- and chloride-dependent GABA transporter 1; GAT-1; solute carrier family 6 member 1; solute carrier family 6 (neurotransmitter transporter, GABA), member 1 |
| UniProt Protein Name: | Sodium- and chloride-dependent GABA transporter 1 |
| UniProt Synonym Protein Names: | Solute carrier family 6 member 1 |
| Protein Family: | Sodium- and chloride-dependent GABA transporter |
| UniProt Gene Name: | SLC6A1 |
| UniProt Entry Name: | SC6A1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC6A1 antibody (CAB15099) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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