Cell Biology Antibodies 15

Anti-SLC5A8 Antibody (CAB18677)

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SKU:
CAB18677
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SLC5A8 Antibody
Antibody SKU:CAB18677
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human SLC5A8.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human SLC5A8.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:160728
Uniprot:Q8N695
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:
Background:
UniProt Protein Function:SLC5A8: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
UniProt Protein Details:

Protein type:Tumor suppressor; Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 12q23.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:monocarboxylic acid transmembrane transporter activity; passive transmembrane transporter activity; symporter activity

Biological Process: ion transport

NCBI Summary:SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]
UniProt Code:Q8N695
NCBI GenInfo Identifier:296452898
NCBI Gene ID:160728
NCBI Accession:Q8N695.2
UniProt Secondary Accession:Q8N695,Q2TB99, Q7Z2H9,
UniProt Related Accession:Q8N695
Molecular Weight:66,578 Da
NCBI Full Name:Sodium-coupled monocarboxylate transporter 1
NCBI Synonym Full Names:solute carrier family 5 member 8
NCBI Official Symbol:SLC5A8  
NCBI Official Synonym Symbols:AIT; SMCT; SMCT1  
NCBI Protein Information:sodium-coupled monocarboxylate transporter 1
UniProt Protein Name:Sodium-coupled monocarboxylate transporter 1
UniProt Synonym Protein Names:Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; Sodium iodide-related cotransporter; Solute carrier family 5 member 8
Protein Family:Sodium-coupled monocarboxylate transporter
UniProt Gene Name:SLC5A8  
UniProt Entry Name:SC5A8_HUMAN
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