Signal Transduction Antibodies 3
Anti-SLC5A5 Antibody (CAB9605)
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- SKU:
- CAB9605
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC5A5 Antibody |
| Antibody SKU: | CAB9605 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 544-643 of human SLC5A5 (NP_000444.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:20 - 1:50 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1, SGC-7901 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 544-643 of human SLC5A5 (NP_000444.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALIS CLTG PTKR STLA PGLL WWDL ARQT ASVA PKEE VAIL DDNL VKGP EELP TGNK KPPG FLPT NEDR LFFL GQKE LEGA GSWT PCVG HDGG RDQQ ETNL |
| Gene ID: | 6528 |
| Uniprot: | Q92911 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 68kDa |
| Observed MW: | 68kDa |
| Synonyms: | SLC5A5, NIS, TDH1 |
| Background: | This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1. |
| UniProt Protein Function: | SLC5A5: Mediates iodide uptake in the thyroid gland. Defects in SLC5A5 are the cause of thyroid dyshormonogenesis 1 (TDH1). A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: integral component of membrane; nucleus; plasma membrane Molecular Function:iodide transmembrane transporter activity; sodium:iodide symporter activity Biological Process: iodide transport; ion transport; thyroid hormone generation; transport Disease: Thyroid Dyshormonogenesis 1 |
| NCBI Summary: | This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q92911 |
| NCBI GenInfo Identifier: | 4507035 |
| NCBI Gene ID: | 6528 |
| NCBI Accession: | NP_000444.1 |
| UniProt Secondary Accession: | Q92911,O43702, Q2M335, Q9NYB6, |
| UniProt Related Accession: | Q92911 |
| Molecular Weight: | |
| NCBI Full Name: | sodium/iodide cotransporter |
| NCBI Synonym Full Names: | solute carrier family 5 member 5 |
| NCBI Official Symbol: | SLC5A5 |
| NCBI Official Synonym Symbols: | NIS; TDH1 |
| NCBI Protein Information: | sodium/iodide cotransporter |
| UniProt Protein Name: | Sodium/iodide cotransporter |
| UniProt Synonym Protein Names: | Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 |
| UniProt Gene Name: | SLC5A5 |
 | Western blot analysis of extracts of various cell lines, using SLC5A5 pAb (CAB9605) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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