Signal Transduction Antibodies 2

Anti-SLC5A12 Antibody (CAB16177)

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SKU:
CAB16177
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SLC5A12 Antibody
Antibody SKU:CAB16177
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-280 of human SLC5A12 (NP_848593.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-29, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-280 of human SLC5A12 (NP_848593.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LIQG STHA GGFH NVLE QSTN GSRL HIFD FDVD PLRR HTFW TITV GGTF TWLG IYGV NQST IQRC ISCK TEKH AKLA LYFN L
Gene ID:159963
Uniprot:Q1EHB4
Cellular Location:Apical cell membrane, Multi-pass membrane protein
Calculated MW:44kDa/67kDa
Observed MW:67kDa
Synonyms:SLC5A12, SMCT2
Background:Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule.
NCBI Summary:Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).[supplied by OMIM, Dec 2008]
UniProt Code:Q1EHB4
NCBI GenInfo Identifier:157671931
NCBI Gene ID:159963
NCBI Accession:NP_848593.2
UniProt Related Accession:Q1EHB4
Molecular Weight:67kDa
NCBI Full Name:sodium-coupled monocarboxylate transporter 2
NCBI Synonym Full Names:solute carrier family 5 member 12
NCBI Official Symbol:SLC5A12  
NCBI Official Synonym Symbols:SMCT2  
NCBI Protein Information:sodium-coupled monocarboxylate transporter 2
UniProt Protein Name:Sodium-coupled monocarboxylate transporter 2
UniProt Synonym Protein Names:Electroneutral sodium monocarboxylate cotransporter; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12
Protein Family:Sodium-coupled monocarboxylate transporter
UniProt Gene Name:SLC5A12  
UniProt Entry Name:SC5AC_HUMAN
Anti-SLC5A12 Antibody (CAB16177)Western blot analysis of extracts of various cell lines, using SLC5A12 antibody (CAB16177) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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