Signal Transduction Antibodies 2
Anti-SLC5A12 Antibody (CAB16177)
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- SKU:
- CAB16177
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC5A12 Antibody |
| Antibody SKU: | CAB16177 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-280 of human SLC5A12 (NP_848593.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-280 of human SLC5A12 (NP_848593.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LIQG STHA GGFH NVLE QSTN GSRL HIFD FDVD PLRR HTFW TITV GGTF TWLG IYGV NQST IQRC ISCK TEKH AKLA LYFN L |
| Gene ID: | 159963 |
| Uniprot: | Q1EHB4 |
| Cellular Location: | Apical cell membrane, Multi-pass membrane protein |
| Calculated MW: | 44kDa/67kDa |
| Observed MW: | 67kDa |
| Synonyms: | SLC5A12, SMCT2 |
| Background: | Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule. |
| NCBI Summary: | Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).[supplied by OMIM, Dec 2008] |
| UniProt Code: | Q1EHB4 |
| NCBI GenInfo Identifier: | 157671931 |
| NCBI Gene ID: | 159963 |
| NCBI Accession: | NP_848593.2 |
| UniProt Related Accession: | Q1EHB4 |
| Molecular Weight: | 67kDa |
| NCBI Full Name: | sodium-coupled monocarboxylate transporter 2 |
| NCBI Synonym Full Names: | solute carrier family 5 member 12 |
| NCBI Official Symbol: | SLC5A12 |
| NCBI Official Synonym Symbols: | SMCT2 |
| NCBI Protein Information: | sodium-coupled monocarboxylate transporter 2 |
| UniProt Protein Name: | Sodium-coupled monocarboxylate transporter 2 |
| UniProt Synonym Protein Names: | Electroneutral sodium monocarboxylate cotransporter; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12 |
| Protein Family: | Sodium-coupled monocarboxylate transporter |
| UniProt Gene Name: | SLC5A12 |
| UniProt Entry Name: | SC5AC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC5A12 antibody (CAB16177) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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