Signal Transduction Antibodies 1
Anti-SLC5A1 Antibody (CAB11976)
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- SKU:
- CAB11976
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC5A1 Antibody |
| Antibody SKU: | CAB11976 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SLC5A1 (NP_000334.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, HeLa, Mouse uterus |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SLC5A1 (NP_000334.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ECEK YCGT KVGC TNIA YPTL VVEL MPNG LRGL MLSV MLAS LMSS LTSI FNSA STLF TMDI YAKV RKRA SEKE LMIA GRLF ILVL IGIS IAWV PIVQ SAQS G |
| Gene ID: | 6523 |
| Uniprot: | P13866 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 60kDa/73kDa |
| Observed MW: | 73kDa |
| Synonyms: | SLC5A1, D22S675, NAGT, SGLT1 |
| Background: | This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SLC5A1: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter Chromosomal Location of Human Ortholog: 22q12.3 Cellular Component: brush border membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; intercellular junction Molecular Function:protein binding; glucose:sodium symporter activity Biological Process: hexose transport; carbohydrate metabolic process; sodium ion transport; pathogenesis; glucose transport; metanephros development; transmembrane transport; intestinal absorption Disease: Glucose/galactose Malabsorption |
| NCBI Summary: | This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P13866 |
| NCBI GenInfo Identifier: | 127803 |
| NCBI Gene ID: | 6523 |
| NCBI Accession: | P13866.1 |
| UniProt Secondary Accession: | P13866,B2R7E2, B7Z4Q9, B7ZA69, |
| UniProt Related Accession: | P13866 |
| Molecular Weight: | 664 |
| NCBI Full Name: | Sodium/glucose cotransporter 1 |
| NCBI Synonym Full Names: | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
| NCBI Official Symbol: | SLC5A1 |
| NCBI Official Synonym Symbols: | NAGT; SGLT1; D22S675 |
| NCBI Protein Information: | sodium/glucose cotransporter 1; Na+/glucose cotransporter 1; high affinity sodium-glucose cotransporter |
| UniProt Protein Name: | Sodium/glucose cotransporter 1 |
| UniProt Synonym Protein Names: | High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 |
| Protein Family: | Sodium/glucose cotransporter |
| UniProt Gene Name: | SLC5A1 |
| UniProt Entry Name: | SC5A1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC5A1 Antibody (CAB11976) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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