Cell Biology Antibodies 17
Anti-SLC52A2 Antibody (CAB18491)
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- SKU:
- CAB18491
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SLC52A2 Antibody |
| Antibody SKU: | CAB18491 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SLC52A2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human SLC52A2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 79581 |
| Uniprot: | Q9HAB3 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | BVVLS2, D15Ertd747e, GPCR41, GPR172A, PAR1, RFT3, RFVT2, hRFT3, SLC52A2 |
| Background: |
| UniProt Protein Function: | GPR172A: Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). Defects in SLC52A2 are the cause of Brown-Vialetto-Van Laere syndrome type 2 (BVVLS2). An autosomal recessive progressive neurologic disorder characterized by early childhood onset of sensorineural deafness, bulbar dysfunction, and severe diffuse muscle weakness and wasting resulting in respiratory insufficiency and loss of independent ambulation. Because it results from a defect in riboflavin metabolism, some patients may benefit from high-dose riboflavin supplementation. Belongs to the riboflavin transporter family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: integral to plasma membrane Molecular Function:protein binding; riboflavin transporter activity; viral receptor activity Biological Process: entry of virus into host cell; riboflavin transport Disease: Brown-vialetto-van Laere Syndrome 2 |
| NCBI Summary: | This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intestine. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene have been associated with Brown-Vialetto-Van Laere syndrome 2 - an autosomal recessive progressive neurologic disorder characterized by deafness, bulbar dysfunction, and axial and limb hypotonia. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q9HAB3 |
| NCBI GenInfo Identifier: | 74734171 |
| NCBI Gene ID: | 79581 |
| NCBI Accession: | Q9HAB3.1 |
| UniProt Secondary Accession: | Q9HAB3,Q86UT1, A8K6B6, D3DWL8, G1UCY1, |
| UniProt Related Accession: | Q9HAB3 |
| Molecular Weight: | 45,777 Da |
| NCBI Full Name: | Solute carrier family 52, riboflavin transporter, member 2 |
| NCBI Synonym Full Names: | solute carrier family 52 member 2 |
| NCBI Official Symbol: | SLC52A2 |
| NCBI Official Synonym Symbols: | PAR1; RFT3; RFVT2; hRFT3; BVVLS2; GPCR41; GPR172A; D15Ertd747e |
| NCBI Protein Information: | solute carrier family 52, riboflavin transporter, member 2 |
| UniProt Protein Name: | Solute carrier family 52, riboflavin transporter, member 2 |
| UniProt Synonym Protein Names: | Porcine endogenous retrovirus A receptor 1; PERV-A receptor 1; Protein GPR172A; Riboflavin transporter 3; hRFT3 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC52A2 |
| UniProt Entry Name: | S52A2_HUMAN |
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