Signal Transduction Antibodies 1

Anti-SLC4A10 Antibody (CAB13810)

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SKU:
CAB13810
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC4A10 Antibody
Antibody SKU:CAB13810
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 640-725 of human SLC4A10 (NP_001171486.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 640-725 of human SLC4A10 (NP_001171486.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ALEK LFEL SEAY PINM HNDL ELLT QYSC NCVE PHNP SNGT LKEW RESN ISAS DIIW ENLT VSEC KSLH GEYV GRAC GHDH PYVP DV
Gene ID:57282
Uniprot:Q6U841
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:46kDa/122kDa/123kDa/125kDa
Observed MW:180kDa
Synonyms:SLC4A10, NBCn2, NCBE
Background:This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniProt Protein Function:Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH.
NCBI Summary:This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
UniProt Code:Q6U841
NCBI GenInfo Identifier:295821221
NCBI Gene ID:57282
NCBI Accession:NP_001171486.1
UniProt Secondary Accession:Q6U841,Q4ZFX6, Q8TCP2, Q9HCQ6, B7Z1R0, B7Z2J0, B7ZLC5 B9EG69, F8W675,
UniProt Related Accession:Q6U841
Molecular Weight:Calculated: 46kDa; 122kDa; 123kDa; 125kDaObserved: 180kDa
NCBI Full Name:sodium-driven chloride bicarbonate exchanger isoform 1
NCBI Synonym Full Names:solute carrier family 4 member 10
NCBI Official Symbol:SLC4A10  
NCBI Official Synonym Symbols:NCBE; NBCn2  
NCBI Protein Information:sodium-driven chloride bicarbonate exchanger
UniProt Protein Name:Sodium-driven chloride bicarbonate exchanger
UniProt Synonym Protein Names:Solute carrier family 4 member 10
Protein Family:Sodium-driven chloride bicarbonate exchanger
UniProt Gene Name:SLC4A10  
Anti-SLC4A10 Antibody (CAB13810)Western blot analysis of extracts of various cell lines, using SLC4A10 antibody (CAB13810) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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