Signal Transduction Antibodies 1

Anti-SLC47A1 Antibody (CAB14559)

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SKU:
CAB14559
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC47A1 Antibody
Antibody SKU:CAB14559
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 460-550 of human SLC47A1 (NP_060712.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Rat
Positive Samples:Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 460-550 of human SLC47A1 (NP_060712.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LNWK KACQ QAQV HANL KVNN VPRS GNSA LPQD PLHP GCPE NLEG ILTN DVGK TGEP QSDQ QMRQ EEPL PEHP QDGA KLSR KQLV LRRG LLL
Gene ID:55244
Uniprot:Q96FL8
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:31kDa/61kDa/63kDa
Observed MW:62kDa
Synonyms:SLC47A1, MATE1
Background:This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function.
UniProt Protein Function:SLC47A1: Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function:drug transporter activity; monovalent cation:proton antiporter activity

Biological Process: multidrug transport; organic cation transport; transmembrane transport

NCBI Summary:This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
UniProt Code:Q96FL8
NCBI GenInfo Identifier:22907060
NCBI Gene ID:55244
NCBI Accession:NP_060712.2
UniProt Related Accession:Q96FL8
Molecular Weight:Calculated MW: 31kDa/61kDa/63kDaObserved MW: 62kDa
NCBI Full Name:multidrug and toxin extrusion protein 1
NCBI Synonym Full Names:solute carrier family 47 member 1
NCBI Official Symbol:SLC47A1  
NCBI Official Synonym Symbols:MATE1  
NCBI Protein Information:multidrug and toxin extrusion protein 1
UniProt Protein Name:Multidrug and toxin extrusion protein 1
UniProt Synonym Protein Names:Solute carrier family 47 member 1
Protein Family:Multidrug and toxin extrusion protein
UniProt Gene Name:SLC47A1  
UniProt Entry Name:S47A1_HUMAN
Anti-SLC47A1 Antibody (CAB14559)Western blot analysis of extracts of rat liver, using SLC47A1 antibody (CAB14559) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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