Signal Transduction Antibodies 2

Anti-SLC40A1 Antibody (CAB14885)

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SKU:
CAB14885
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC40A1 Antibody
Antibody SKU:CAB14885
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SLC40A1 (NP_055400.1).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SLC40A1 (NP_055400.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SPVI GCGF ISGW NLVS MCVE YVLL WKVY QKTP ALAV KAGL KEEE TELK QLNL HKDT EPKP LEGT HLMG VKDS NIHE LEHE QEPT CASQ MAEP FRTF RDGW V
Gene ID:30061
Uniprot:Q9NP59
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:62kDa
Observed MW:
Synonyms:SLC40A1, FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3
Background:The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).
UniProt Protein Function:SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: multivesicular body; synaptic vesicle; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; integral to membrane; intracellular

Molecular Function:iron ion transmembrane transporter activity; protein binding

Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; lymphocyte homeostasis; transmembrane transport; negative regulation of apoptosis

Disease: Hemochromatosis, Type 4

NCBI Summary:The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
UniProt Code:Q9NP59
NCBI GenInfo Identifier:67633296
NCBI Gene ID:30061
NCBI Accession:AAY78556.1
UniProt Secondary Accession:Q9NP59,Q6FI62, Q7Z4F8, Q8IVB2, Q9NRL0,
UniProt Related Accession:Q9NP59
Molecular Weight:62,542 Da
NCBI Full Name:ferroportin 1 variant I, partial
NCBI Synonym Full Names:solute carrier family 40 (iron-regulated transporter), member 1
NCBI Official Symbol:SLC40A1  
NCBI Official Synonym Symbols:FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3  
NCBI Protein Information:solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
UniProt Protein Name:Solute carrier family 40 member 1
UniProt Synonym Protein Names:Ferroportin-1; Iron-regulated transporter 1
UniProt Gene Name:SLC40A1  
UniProt Entry Name:S40A1_HUMAN
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