Name: Anti-SLC39A7 Antibody (CAB3343)
Brand: Signal Transduction Antibodies 2
SKU: CAB3343
Availability: OutOfStock

Antibody Name:	Anti-SLC39A7 Antibody
Antibody SKU:	CAB3343
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 235-380 of human SLC39A7 (NP_008910.2).

Application:	WB IHC
Recommended Dilution:	WB 1:1000 - 1:3000 IHC 1:100 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, A-431, LO2, HeLa, Mouse heart, Mouse pancreas, Mouse liver, Rat heart

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 235-380 of human SLC39A7 (NP_008910.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	KFVR HVKG GHGH SHGH GHAH SHTR GSHG HGRQ ERST KEKQ SSEE EEKE TRGV QKRR GGST VPKD GPVR PQNA EEEK RGLD LRVS GYLN LAAD LAHN FTDG LAIG ASFR GGRG LGIL TTMT VLLH EVPH EVGD FAIL VQSG CSKK QA
Gene ID:	7922
Uniprot:	Q92504
Cellular Location:	Endoplasmic reticulum membrane, Golgi apparatus, Multi-pass membrane protein, cis-Golgi network membrane
Calculated MW:	50kDa
Observed MW:	50kDa

Synonyms:	SLC39A7, D6S115E, D6S2244E, H2-KE4, HKE4, KE4, RING5, ZIP7
Background:	The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	SLC39A7: transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Protein Details:	Protein type:Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane Molecular Function:metal ion transmembrane transporter activity; protein binding Biological Process: zinc ion transport; transmembrane transport
NCBI Summary:	The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Code:	Q92504
NCBI GenInfo Identifier:	12643344
NCBI Gene ID:	7922
NCBI Accession:	Q92504.2
UniProt Secondary Accession:	Q92504,Q5STP8, Q9UIQ0, B0UXF6,
UniProt Related Accession:	Q92504
Molecular Weight:	469
NCBI Full Name:	Zinc transporter SLC39A7
NCBI Synonym Full Names:	solute carrier family 39 (zinc transporter), member 7
NCBI Official Symbol:	SLC39A7
NCBI Official Synonym Symbols:	KE4; HKE4; ZIP7; RING5; H2-KE4; D6S115E; D6S2244E
NCBI Protein Information:	zinc transporter SLC39A7; zrt-, Irt-like protein 7; Ke4 gene, mouse, human homolog of; solute carrier family 39 member 7; histidine-rich membrane protein Ke4; really interesting new gene 5 protein; HLA class II region expressed gene KE4
UniProt Protein Name:	Zinc transporter SLC39A7
UniProt Synonym Protein Names:	Histidine-rich membrane protein Ke4; Really interesting new gene 5 protein; Solute carrier family 39 member 7; Zrt-, Irt-like protein 7; ZIP7
Protein Family:	Zinc transporter
UniProt Gene Name:	SLC39A7
UniProt Entry Name:	S39A7_HUMAN

	Western blot analysis of extracts of various cell lines, using SLC39A7 antibody (CAB3343) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s.
	Immunohistochemistry of paraffin-embedded rat testis using SLC39A7 antibody (CAB3343) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded rat kidney using SLC39A7 antibody (CAB3343) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human liver using SLC39A7 antibody (CAB3343) at dilution of 1:100 (40x lens).