Antibody Name:	Anti-SLC37A4 Antibody
Antibody SKU:	CAB14564
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human SLC37A4 (NP_001157752.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse kidney, Rat liver

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human SLC37A4 (NP_001157752.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	RHGL LLFM MAGM TVSM YLFR VTVT SDSP KLWI LVLG AVFG FSSY GPIA LFGV IANE SAPP NLCG TSHA IVGL MANV GGFL AGLP FSTI AKHY SWST AFWV AEVI CAAS TAAF FLLR NIRT KMGR VSKK AE
Gene ID:	2542
Uniprot:	O43826
Cellular Location:	Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:	46kDa/48kDa
Observed MW:	46kDa

Synonyms:

SLC37A4, G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, PRO0685, TRG-19, TRG19

Background:

This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.

UniProt Protein Function:	SLC37A4: Transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6- phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. Defects in SLC37A4 are the cause of glycogen storage disease type 1B (GSD1B). GSD1B is a metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. GSD1 patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. GSD1B patients also present a tendency towards infections associated with neutropenia, relapsing aphthous gingivostomatitis, and inflammatory bowel disease. Defects in SLC37A4 are the cause of glycogen storage disease type 1C (GSD1C). Defects in SLC37A4 are the cause of glycogen storage disease type 1D (GSD1D). Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane; integral to endoplasmic reticulum membrane Molecular Function:transporter activity; glucose-6-phosphate transmembrane transporter activity Biological Process: glucose-6-phosphate transport; transport; hexose transport; carbohydrate metabolic process; glucose metabolic process; pathogenesis; glucose transport; glucose homeostasis; transmembrane transport Disease: Glycogen Storage Disease Ic; Glycogen Storage Disease Ib
NCBI Summary:	This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]
UniProt Code:	O43826
NCBI GenInfo Identifier:	40352813
NCBI Gene ID:	2542
NCBI Accession:	AAH64563.1
UniProt Secondary Accession:	O43826,O96016, Q5J7V4, Q9UI19, Q9UNS4,
UniProt Related Accession:	O43826
Molecular Weight:	48,840 Da
NCBI Full Name:	Solute carrier family 37 (glucose-6-phosphate transporter), member 4
NCBI Synonym Full Names:	solute carrier family 37 (glucose-6-phosphate transporter), member 4
NCBI Official Symbol:	SLC37A4
NCBI Official Synonym Symbols:	G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG19; TRG-19; PRO0685
NCBI Protein Information:	glucose-6-phosphate translocase; glucose-5-phosphate transporter; transformation-related gene 19 protein; microsomal glucose-6-phosphate transporter; glucose-6-phosphatase, transport (glucose) protein 3; glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1; glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2
UniProt Protein Name:	Glucose-6-phosphate translocase
UniProt Synonym Protein Names:	Glucose-5-phosphate transporter; Solute carrier family 37 member 4; Transformation-related gene 19 protein; TRG-19
Protein Family:	Glucose-6-phosphate exchanger
UniProt Gene Name:	SLC37A4
UniProt Entry Name:	G6PT1_HUMAN

	Western blot analysis of extracts of various cell lines, using SLC37A4 antibody (CAB14564) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded rat brain using SLC37A4 antibody (CAB14564) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human liver using SLC37A4 antibody (CAB14564) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse lung using SLC37A4 antibody (CAB14564) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse brain using SLC37A4 antibody (CAB14564) at dilution of 1:100 (40x lens).