Cell Biology Antibodies 16
Anti-SLC35A1 Antibody (CAB10658)
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- SKU:
- CAB10658
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SLC35A1 Antibody |
| Antibody SKU: | CAB10658 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SLC35A1 (NP_006407.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SLC35A1 (NP_006407.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAP RDNV TLLF KLYC LAVM TLMA AVYT IALR YTRT SDKE LYFS TTAV CITE VIKL LLSV GILA KETG SLGR FKAS LREN VLGS PKEL LKLS VPSL VYAV |
| Gene ID: | 10559 |
| Uniprot: | P78382 |
| Cellular Location: | Golgi apparatus membrane, Multi-pass membrane protein |
| Calculated MW: | 29kDa/36kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SLC35A1, CDG2F, CMPST, CST, hCST |
| Background: | The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SLC35A1: Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. Defects in SLC35A1 are the cause of congenital disorder of glycosylation type 2F (CDG2F). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family Chromosomal Location of Human Ortholog: 6q15 Cellular Component: Golgi membrane; Golgi apparatus; integral to plasma membrane Molecular Function:CMP-sialic acid transmembrane transporter activity; sugar:hydrogen ion symporter activity Biological Process: proton transport; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; carbohydrate metabolic process; carbohydrate transport; protein modification process; protein amino acid N-linked glycosylation via asparagine; CMP-sialic acid transport; post-translational protein modification; transmembrane transport Disease: Congenital Disorder Of Glycosylation, Type Iif |
| NCBI Summary: | The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] |
| UniProt Code: | P78382 |
| NCBI GenInfo Identifier: | 2499226 |
| NCBI Gene ID: | 10559 |
| NCBI Accession: | P78382.1 |
| UniProt Secondary Accession: | P78382,Q5W1L8, |
| UniProt Related Accession: | P78382 |
| Molecular Weight: | 29,919 Da |
| NCBI Full Name: | CMP-sialic acid transporter |
| NCBI Synonym Full Names: | solute carrier family 35 (CMP-sialic acid transporter), member A1 |
| NCBI Official Symbol: | SLC35A1 |
| NCBI Official Synonym Symbols: | CST; hCST; CDG2F; CMPST |
| NCBI Protein Information: | CMP-sialic acid transporter; CMP-SA-Tr; CMP-Sia-Tr; solute carrier family 35 member A1; mutated CMP-sialic acid transporter A1; solute carrier family 35 (UDP-galactose transporter), member 1; solute carrier family 35 (CMP-sialic acid transporter), member 1 |
| UniProt Protein Name: | CMP-sialic acid transporter |
| UniProt Synonym Protein Names: | Solute carrier family 35 member A1 |
| Protein Family: | CMP-sialic acid transporter |
| UniProt Gene Name: | SLC35A1 |
| UniProt Entry Name: | S35A1_HUMAN |
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