Signal Transduction Antibodies 2

Anti-SLC30A7 Antibody (CAB5172)

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SKU:
CAB5172
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC30A7 Antibody
Antibody SKU:CAB5172
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 287-376 of human SLC30A7 (NP_598003.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 287-376 of human SLC30A7 (NP_598003.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RESV GILM QRTP PLLE NSLP QCYQ RVQQ LQGV YSLQ EQHF WTLC SDVY VGTL KLIV APDA DARW ILSQ THNI FTQA GVRQ LYVQ IDFA AM
Gene ID:148867
Uniprot:Q8NEW0
Cellular Location:Golgi apparatus, Multi-pass membrane protein, trans-Golgi network membrane
Calculated MW:41kDa
Observed MW:Refer to figures
Synonyms:SLC30A7, ZNT7, ZnT-7, ZnTL2
Background:
UniProt Protein Function:SLC30A7: Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
UniProt Protein Details:

Protein type:Transporter; Transporter, SLC family; Membrane protein, integral; Vesicle; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p21.2

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasm; integral to membrane; vesicle

Molecular Function:cation transmembrane transporter activity

Biological Process: sequestering of zinc ion; cellular protein metabolic process; zinc ion transport; transmembrane transport

NCBI Summary:Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]
UniProt Code:Q8NEW0
NCBI GenInfo Identifier:74751261
NCBI Gene ID:148867
NCBI Accession:Q8NEW0.1
UniProt Secondary Accession:Q8NEW0,Q8TCH2, B2R949, D3DT61,
UniProt Related Accession:Q8NEW0
Molecular Weight:41kDa
NCBI Full Name:Zinc transporter 7
NCBI Synonym Full Names:solute carrier family 30 (zinc transporter), member 7
NCBI Official Symbol:SLC30A7  
NCBI Official Synonym Symbols:ZNT7; ZnT-7; ZnTL2  
NCBI Protein Information:zinc transporter 7; zinc transporter ZnT-7; znt-like transporter 2; zinc transporter like 2; solute carrier family 30 member 7
UniProt Protein Name:Zinc transporter 7
UniProt Synonym Protein Names:Solute carrier family 30 member 7; Znt-like transporter 2
Protein Family:Zinc transporter
UniProt Gene Name:SLC30A7  
UniProt Entry Name:ZNT7_HUMAN
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