Signal Transduction Antibodies 1

Anti-SLC30A4 Antibody (CAB13053)

(No reviews yet) Write a Review
SKU:
CAB13053
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SLC30A4 Antibody
Antibody SKU:CAB13053
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 335-429 of human SLC30A4 (NP_037441.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:A-549, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 335-429 of human SLC30A4 (NP_037441.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VPSH LNVD YIKE ALMK IEDV YSVE DLNI WSLT SGKS TAIV HIQL IPGS SSKW EEVQ SKAN HLLL NTFG MYRC TIQL QSYR QEVD RTCA NCQS SSP
Gene ID:7782
Uniprot:O14863
Cellular Location:Endosome membrane, Late endosome membrane, Lysosome membrane, Multi-pass membrane protein
Calculated MW:47kDa
Observed MW:47kDa
Synonyms:SLC30A4, ZNT4, znT-4
Background:
UniProt Protein Function:SLC30A4: Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 15q21.1|15q21.1

Cellular Component: late endosome; cytoplasm; integral to membrane; endosome membrane

Molecular Function:zinc ion transmembrane transporter activity

Biological Process: zinc ion homeostasis; response to toxin

NCBI Summary:Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]
UniProt Code:O14863
NCBI GenInfo Identifier:206729947
NCBI Gene ID:7782
NCBI Accession:O14863.2
UniProt Secondary Accession:O14863,Q8TC39,
UniProt Related Accession:O14863
Molecular Weight:
NCBI Full Name:Zinc transporter 4
NCBI Synonym Full Names:solute carrier family 30 (zinc transporter), member 4
NCBI Official Symbol:SLC30A4  
NCBI Official Synonym Symbols:ZNT4  
NCBI Protein Information:zinc transporter 4; znT-4; solute carrier family 30 member 4
UniProt Protein Name:Zinc transporter 4
UniProt Synonym Protein Names:Solute carrier family 30 member 4
Protein Family:Zinc transporter
UniProt Gene Name:SLC30A4  
UniProt Entry Name:ZNT4_HUMAN
Anti-SLC30A4 Antibody (CAB13053)Western blot analysis of extracts of various cell lines, using SLC30A4 Antibody (CAB13053) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products