Signal Transduction Antibodies 1
Anti-SLC30A4 Antibody (CAB13053)
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- SKU:
- CAB13053
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC30A4 Antibody |
| Antibody SKU: | CAB13053 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 335-429 of human SLC30A4 (NP_037441.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 335-429 of human SLC30A4 (NP_037441.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VPSH LNVD YIKE ALMK IEDV YSVE DLNI WSLT SGKS TAIV HIQL IPGS SSKW EEVQ SKAN HLLL NTFG MYRC TIQL QSYR QEVD RTCA NCQS SSP |
| Gene ID: | 7782 |
| Uniprot: | O14863 |
| Cellular Location: | Endosome membrane, Late endosome membrane, Lysosome membrane, Multi-pass membrane protein |
| Calculated MW: | 47kDa |
| Observed MW: | 47kDa |
| Synonyms: | SLC30A4, ZNT4, znT-4 |
| Background: |
| UniProt Protein Function: | SLC30A4: Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter Chromosomal Location of Human Ortholog: 15q21.1|15q21.1 Cellular Component: late endosome; cytoplasm; integral to membrane; endosome membrane Molecular Function:zinc ion transmembrane transporter activity Biological Process: zinc ion homeostasis; response to toxin |
| NCBI Summary: | Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | O14863 |
| NCBI GenInfo Identifier: | 206729947 |
| NCBI Gene ID: | 7782 |
| NCBI Accession: | O14863.2 |
| UniProt Secondary Accession: | O14863,Q8TC39, |
| UniProt Related Accession: | O14863 |
| Molecular Weight: | |
| NCBI Full Name: | Zinc transporter 4 |
| NCBI Synonym Full Names: | solute carrier family 30 (zinc transporter), member 4 |
| NCBI Official Symbol: | SLC30A4 |
| NCBI Official Synonym Symbols: | ZNT4 |
| NCBI Protein Information: | zinc transporter 4; znT-4; solute carrier family 30 member 4 |
| UniProt Protein Name: | Zinc transporter 4 |
| UniProt Synonym Protein Names: | Solute carrier family 30 member 4 |
| Protein Family: | Zinc transporter |
| UniProt Gene Name: | SLC30A4 |
| UniProt Entry Name: | ZNT4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC30A4 Antibody (CAB13053) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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