Signal Transduction Antibodies 2

Anti-SLC2A8 Antibody (CAB16521)

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SKU:
CAB16521
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC2A8 Antibody
Antibody SKU:CAB16521
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-260 of human SLC2A8 (NP_055395.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse testis, Mouse brain, Mouse heart, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-260 of human SLC2A8 (NP_055395.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CFMP ETPR FLLT QHRR QEAM AALR FLWG SEQG WEDP PIGA EQSF HLAL LRQP GIYK PFII G
Gene ID:29988
Uniprot:Q9NY64
Cellular Location:Cell membrane, Cytoplasmic vesicle membrane, Multi-pass membrane protein
Calculated MW:50kDa
Observed MW:51kDa
Synonyms:SLC2A8, GLUT8, GLUTX1
Background:This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene.
UniProt Protein Function:SLC2A8: Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
UniProt Protein Details:

Protein type:Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: cytoplasmic vesicle membrane; integral to plasma membrane; lysosomal membrane; plasma membrane; synaptic vesicle

Molecular Function:D-glucose transmembrane transporter activity; glucose binding; glucose transmembrane transporter activity; sugar:hydrogen ion symporter activity

Biological Process: carbohydrate metabolic process; glucose import; glucose transport; insulin receptor signaling pathway; male meiosis I; proton transport; response to hypoxia

NCBI Summary:This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
UniProt Code:Q9NY64
NCBI GenInfo Identifier:145559479
NCBI Gene ID:29988
NCBI Accession:Q9NY64.3
UniProt Secondary Accession:Q9NY64,Q8WUZ9, Q9NSC4,
UniProt Related Accession:Q9NY64
Molecular Weight:50,819 Da
NCBI Full Name:Solute carrier family 2, facilitated glucose transporter member 8
NCBI Synonym Full Names:solute carrier family 2 member 8
NCBI Official Symbol:SLC2A8  
NCBI Official Synonym Symbols:GLUT8; GLUTX1  
NCBI Protein Information:solute carrier family 2, facilitated glucose transporter member 8
UniProt Protein Name:Solute carrier family 2, facilitated glucose transporter member 8
UniProt Synonym Protein Names:Glucose transporter type 8; GLUT-8; Glucose transporter type X1
Protein Family:Solute carrier family
UniProt Gene Name:SLC2A8  
UniProt Entry Name:GTR8_HUMAN
Anti-SLC2A8 Antibody (CAB16521)Western blot analysis of extracts of various cell lines, using SLC2A8 antibody (CAB16521) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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