Signal Transduction Antibodies 1
Anti-SLC29A1 Antibody (CAB13205)
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- SKU:
- CAB13205
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC29A1 Antibody |
| Antibody SKU: | CAB13205 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SLC29A1 (NP_001071645.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Rat lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SLC29A1 (NP_001071645.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ELSE SAFG YFIT ACAV IILT IICY LGLP RLEF YRYY QQLK LEGP GEQE TKLD LISK GEEP RAGK EESG VSVS NSQP TNES HSIK AILK NISV LAFS VCFI F |
| Gene ID: | 2030 |
| Uniprot: | Q99808 |
| Cellular Location: | Apical cell membrane, Basolateral cell membrane, Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 50kDa/58kDa |
| Observed MW: | 55kDa |
| Synonyms: | SLC29A1, ENT1 |
| Background: | This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. |
| UniProt Protein Function: | SLC29A1: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: apical plasma membrane; basolateral plasma membrane; membrane; plasma membrane Molecular Function:nucleoside transmembrane transporter activity Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleoside transport |
| NCBI Summary: | This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99808 |
| NCBI GenInfo Identifier: | 9296956 |
| NCBI Gene ID: | 2030 |
| NCBI Accession: | Q99808.3 |
| UniProt Secondary Accession: | Q99808,Q5T9W9, Q9UJY2, B3KQV7, B3KQY5, |
| UniProt Related Accession: | Q99808 |
| Molecular Weight: | 58,963 Da |
| NCBI Full Name: | Equilibrative nucleoside transporter 1 |
| NCBI Synonym Full Names: | solute carrier family 29 member 1 (Augustine blood group) |
| NCBI Official Symbol: | SLC29A1 |
| NCBI Official Synonym Symbols: | ENT1 |
| NCBI Protein Information: | equilibrative nucleoside transporter 1 |
| UniProt Protein Name: | Equilibrative nucleoside transporter 1 |
| UniProt Synonym Protein Names: | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1 |
| Protein Family: | Equilibrative nucleoside transporter |
| UniProt Gene Name: | SLC29A1 |
| UniProt Entry Name: | S29A1_HUMAN |
 | Western blot analysis of extracts of rat lung, using SLC29A1 antibody (CAB13205) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of NIH/3T3 cells using SLC29A1 antibody (CAB13205) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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