Name: Anti-SLC27A4 Antibody (CAB16102)
Brand: Metabolism Antibodies 3
SKU: CAB16102
Availability: OutOfStock

Antibody Name:	Anti-SLC27A4 Antibody
Antibody SKU:	CAB16102
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 574-643 of human SLC27A4 (NP_005085.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	U-87MG, HT-29, A-431, Mouse brain, Mouse liver, Rat heart

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 574-643 of human SLC27A4 (NP_005085.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	PLYA RPIF LRLL PELH KTGT YKFQ KTEL RKEG FDPA IVKD PLFY LDAQ KGRY VPLD QEAY SRIQ AGEE KL
Gene ID:	10999
Uniprot:	Q6P1M0
Cellular Location:	Endoplasmic reticulum membrane, Membrane, Multi-pass membrane protein
Calculated MW:	26kDa/72kDa
Observed MW:	72kDa

Synonyms:

SLC27A4, ACSVL4, FATP4, IPS

Background:

This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome.

UniProt Protein Function:	SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family; EC 6.2.1.-; Ligase Chromosomal Location of Human Ortholog: 9q34.11 Cellular Component: endoplasmic reticulum membrane; microvillus; membrane; brush border membrane; integral to membrane; plasma membrane Molecular Function:fatty acid transporter activity; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity Biological Process: long-chain fatty acid transport; skin development; transport; very-long-chain fatty acid catabolic process; long-chain fatty acid metabolic process; lipid metabolic process; medium-chain fatty acid transport; transmembrane transport; fatty acid transport; response to nutrient Disease: Ichthyosis Prematurity Syndrome
NCBI Summary:	This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]
UniProt Code:	Q6P1M0
NCBI GenInfo Identifier:	40807357
NCBI Gene ID:	10999
NCBI Accession:	NP_005085.2
UniProt Related Accession:	Q6P1M0
Molecular Weight:	Observed: 70 kDaPredicted: 73 kDa
NCBI Full Name:	long-chain fatty acid transport protein 4
NCBI Synonym Full Names:	solute carrier family 27 member 4
NCBI Official Symbol:	SLC27A4
NCBI Official Synonym Symbols:	IPS; FATP4; ACSVL4
NCBI Protein Information:	long-chain fatty acid transport protein 4
UniProt Protein Name:	Long-chain fatty acid transport protein 4
UniProt Synonym Protein Names:	Solute carrier family 27 member 4
UniProt Gene Name:	SLC27A4
UniProt Entry Name:	S27A4_HUMAN

Western blot analysis of extracts of various cell lines, using SLC27A4 antibody (CAB16102) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

Anti-SLC27A4 Antibody (CAB16101)

Anti-SLC27A4 Antibody (CAB7579)

SLC27A4 Antibody (PACO03372)

SLC27A4 Antibody (PACO12278)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)