Name: Anti-SLC26A2 Antibody (CAB6369)
Brand: Signal Transduction Antibodies 3
SKU: CAB6369
Availability: OutOfStock

Antibody Name:	Anti-SLC26A2 Antibody
Antibody SKU:	CAB6369
Antibody Size:	20uL, 50uL, 100uL
Application:	IF
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 540-739 of human SLC26A2 (NP_000103.2).

Application:	IF
Recommended Dilution:	IF 1:50 - 1:100
Reactivity:	Human
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 540-739 of human SLC26A2 (NP_000103.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	FCVI LRTQ KPKS SLLG LVEE SEVF ESVS AYKN LQIK PGIK IFRF VAPL YYIN KECF KSAL YKQT VNPI LIKV AWKK AAKR KIKE KVVT LGGI QDEM SVQL SHDP LELH TIVI DCSA IQFL DTAG IHTL KEVR RDYE AIGI QVLL AQCN PTVR DSLT NGEY CKKE EENL LFYS VYEA MAFA EVSK NQKG VCVP NGLS LSSD
Gene ID:	1836
Uniprot:	P50443
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	81kDa
Observed MW:	Refer to Figures

Synonyms:	SLC26A2, D5S1708, DTD, DTDST, EDM4, MST153, MSTP157
Background:	The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization.

UniProt Protein Function:	SLC26A2: Sulfate transporter. May play a role in endochondral bone formation. Defects in SLC26A2 are the cause of diastrophic dysplasia (DTD). DTD is an autosomal recessive disease characterized by osteochondrodysplasia with clinical features including dwarfism, spinal deformation, and specific joint abnormalities. Defects in SLC26A2 are the cause of achondrogenesis type 1B (ACG1B). ACG1B is a recessively inherited chondrodysplasia characterized by extremely poor skeletal development and perinatal death. Defects in SLC26A2 are the cause of atelosteogenesis type 2 (AO2); also known as neonatal osseous dysplasia 1. AO2 is characterized by severely shortened limbs, small chest, scoliosis, club foot of the equinovarus type (talipes equinovarus), abducted thumbs and great toes, and cleft palate. Patients die of respiratory insufficiency shortly after birth because of the collapse of the airways and pulmonary hypoplasia due to the small rib cage. Defects in SLC26A2 are the cause of multiple epiphyseal dysplasia type 4 (EDM4). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM4 is a recessively inherited form, characterized by early childhood-onset hip dysplasia and recurrent patella dislocation. Short stature in EDM4 patients is not frequent. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
UniProt Protein Details:	Protein type:Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q31-q34 Cellular Component: membrane; integral to plasma membrane; plasma membrane Molecular Function:sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity Biological Process: ossification; glycosaminoglycan metabolic process; xenobiotic metabolic process; carbohydrate metabolic process; sulfate transport; ion transport; pathogenesis; transmembrane transport; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process Disease: Atelosteogenesis, Type Ii; Diastrophic Dysplasia; Achondrogenesis, Type Ib; Epiphyseal Dysplasia, Multiple, 4
NCBI Summary:	The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008]
UniProt Code:	P50443
NCBI GenInfo Identifier:	254763328
NCBI Gene ID:	1836
NCBI Accession:	P50443.2
UniProt Secondary Accession:	P50443,Q6N051, A8K2U3, B2R6J1,
UniProt Related Accession:	P50443
Molecular Weight:	739
NCBI Full Name:	Sulfate transporter
NCBI Synonym Full Names:	solute carrier family 26 (anion exchanger), member 2
NCBI Official Symbol:	SLC26A2
NCBI Official Synonym Symbols:	DTD; EDM4; DTDST; MST153; D5S1708; MSTP157
NCBI Protein Information:	sulfate transporter; sulfate anion transporter 1; diastrophic dysplasia protein; solute carrier family 26 (sulfate transporter), member 2
UniProt Protein Name:	Sulfate transporter
UniProt Synonym Protein Names:	Diastrophic dysplasia protein; Solute carrier family 26 member 2
Protein Family:	Sulfate transporter
UniProt Gene Name:	SLC26A2
UniProt Entry Name:	S26A2_HUMAN