Signal Transduction Antibodies 2

Anti-SLC26A11 Antibody (CAB17276)

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SKU:
CAB17276
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC26A11 Antibody
Antibody SKU:CAB17276
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SLC26A11 (NP_001159819.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SLC26A11 (NP_001159819.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EILS RALE VSPP RCLV LECT HVCS IDYT VVLG LGEL LQDF QKQG VALA FVGL QVPV LRVL LSAD LKGF QYFS TLEE AEKH LRQE PGTQ PYNI REDS ILDQ K
Gene ID:284129
Uniprot:Q86WA9
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:SLC26A11
Background:This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4, 4'-diisothiocyanostilbene-2, 2'-disulfonic acid. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:SLC26A11: Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC). Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; lysosomal membrane; nucleoplasm; plasma membrane

Molecular Function:anion transmembrane transporter activity; anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; oxalate transmembrane transporter activity; sulfate transmembrane transporter activity

Biological Process: bicarbonate transport; regulation of intracellular pH; regulation of membrane potential; sulfate transport

NCBI Summary:This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
UniProt Code:Q86WA9
NCBI GenInfo Identifier:23273535
NCBI Gene ID:284129
NCBI Accession:BC035900
UniProt Secondary Accession:Q86WA9,Q86VX1, Q86YX7, Q8IV11, Q8N2I1, Q8NG03, B2RCI7
UniProt Related Accession:Q86WA9
Molecular Weight:65,299 Da
NCBI Full Name:Homo sapiens solute carrier family 26, member 11, mRNA
NCBI Synonym Full Names:solute carrier family 26 member 11
NCBI Official Symbol:SLC26A11  
NCBI Protein Information:sodium-independent sulfate anion transporter
UniProt Protein Name:Sodium-independent sulfate anion transporter
UniProt Synonym Protein Names:Solute carrier family 26 member 11
Protein Family:Sodium-independent sulfate anion transporter
UniProt Gene Name:SLC26A11  
UniProt Entry Name:S2611_HUMAN
Anti-SLC26A11 Antibody (CAB17276)Western blot analysis of extracts of various cell lines, using SLC26A11 antibody (CAB17276) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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