Cell Death Antibodies 1
Anti-SLC25A6 Antibody (CAB15029)
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- SKU:
- CAB15029
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-SLC25A6 Antibody |
| Antibody SKU: | CAB15029 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human SLC25A6 (NP_001627.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human SLC25A6 (NP_001627.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTEQ AISF AKDF LAGG IAAA ISKT AVAP IERV KLLL QVQH ASKQ IAAD KQYK GIVD CIVR IPKE QGVL SFWR GNLA NVIR YFPT QALN FAFK DKYK QIFL GGVD KHTQ FWRY FAGN LASG GAAG ATSL CFVY PLDF ARTR LAAD VGKS GTER EFRG LGDC LVKI TKSD GIRG LYQG FSVS VQGI IIYR AAYF GVYD TAKG MLPD PKNT HIVV SWMI AQTV TAVA GVVS YPFD TVRR RMMM QSGR KGAD IMYT GTVD CWRK IFRD EGGK AFFK GAWS NVLR GMGG AFVL VLYD ELKK VI |
| Gene ID: | 293 |
| Uniprot: | P12236 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 32kDa |
| Observed MW: |
| Synonyms: | SLC25A6, AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y, ANT2 |
| Background: | This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. |
| UniProt Protein Function: | SLC25A6: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Belongs to the mitochondrial carrier family. |
| UniProt Protein Details: | Protein type:Transporter; Transporter, SLC family; Mitochondrial; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3 Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; nucleus; mitochondrial inner membrane presequence translocase complex Molecular Function:protein binding; ATP:ADP antiporter activity Biological Process: ATP transport; ADP transport; cellular protein metabolic process; viral reproduction; apoptosis; active induction of host immune response by virus; virus-host interaction; energy reserve metabolic process; viral infectious cycle; regulation of insulin secretion; protein targeting to mitochondrion; transmembrane transport |
| NCBI Summary: | This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013] |
| UniProt Code: | P12236 |
| NCBI GenInfo Identifier: | 113463 |
| NCBI Gene ID: | 293 |
| NCBI Accession: | P12236.4 |
| UniProt Secondary Accession: | P12236,Q96C49, |
| UniProt Related Accession: | P12236 |
| Molecular Weight: | 298 |
| NCBI Full Name: | ADP/ATP translocase 3 |
| NCBI Synonym Full Names: | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
| NCBI Official Symbol: | SLC25A6 |
| NCBI Official Synonym Symbols: | 2; 3; ANT; AAC3; ANT3; ANT 2; ANT 3; ANT3Y |
| NCBI Protein Information: | ADP/ATP translocase 3; ADP,ATP carrier protein 3; ADP/ATP translocator of liver; ADP,ATP carrier protein, liver; adenine nucleotide translocator 3; solute carrier family 25 member 6; ADP,ATP carrier protein, isoform T2 |
| UniProt Protein Name: | ADP/ATP translocase 3 |
| UniProt Synonym Protein Names: | ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6ADP/ATP translocase 3, N-terminally processed |
| Protein Family: | ADP/ATP translocase |
| UniProt Gene Name: | SLC25A6 |
| UniProt Entry Name: | ADT3_HUMAN |
 | Immunofluorescence analysis of U2OS cells using SLC25A6 antibody (CAB15029) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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