Immunology Antibodies 1

Anti-SLC25A4 Antibody (CAB15027)

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SKU:
CAB15027
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-SLC25A4 Antibody
Antibody SKU:CAB15027
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-298 of human SLC25A4 (NP_001142.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-298 of human SLC25A4 (NP_001142.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HASK QISA EKQY KGII DCVV RIPK EQGF LSFW RGNL ANVI RYFP TQAL NFAF KDKY KQLF LGGV DRHK QFWR YFAG NLAS GGAA GATS LCFV YPLD FART RLAA DVGK GAAQ REFH GLGD CIIK IFKS DGLR GLYQ GFNV SVQG IIIY RAAY FGVY DTAK GMLP DPKN VHIF VSWM IAQS VTAV AGLV SYPF DTVR RRMM MQSG RKGA DIMY TGTV DCWR KIAK DEGA KAFF KGAW SNVL RGMG GAFV LVLY DEIK KYV
Gene ID:291
Uniprot:P12235
Cellular Location:Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:33kDa
Observed MW:Refer to figures
Synonyms:SLC25A4, AAC1, ANT, ANT 1, ANT1, MTDPS12, MTDPS12A, PEO2, PEO3, PEOA2, T1
Background:This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy.
UniProt Protein Function:SLC25A4: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. Defects in SLC25A4 are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 2 (PEOA2). Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged- red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. Belongs to the mitochondrial carrier family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family; Mitochondrial

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: mitochondrion; integral to plasma membrane; mitochondrial inner membrane; nucleus

Molecular Function:protein binding; adenine transmembrane transporter activity

Biological Process: adenine transport; mitochondrial genome maintenance; apoptotic mitochondrial changes; generation of precursor metabolites and energy; viral reproduction; transport; energy reserve metabolic process; regulation of insulin secretion; transmembrane transport

Disease: Mitochondrial Dna Depletion Syndrome 12 (cardiomyopathic Type); Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 2

NCBI Summary:This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]
UniProt Code:P12235
NCBI GenInfo Identifier:113455
NCBI Gene ID:291
NCBI Accession:P12235.4
UniProt Secondary Accession:P12235,D3DP59,
UniProt Related Accession:P12235
Molecular Weight:298
NCBI Full Name:ADP/ATP translocase 1
NCBI Synonym Full Names:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
NCBI Official Symbol:SLC25A4  
NCBI Official Synonym Symbols:1; T1; ANT; AAC1; ANT1; PEO2; PEO3; ANT 1; MTDPS12  
NCBI Protein Information:ADP/ATP translocase 1; ADP,ATP carrier protein 1; solute carrier family 25 member 4; heart/skeletal muscle ATP/ADP translocator; ADP,ATP carrier protein, heart/skeletal muscle; adenine nucleotide translocator 1 (skeletal muscle)
UniProt Protein Name:ADP/ATP translocase 1
UniProt Synonym Protein Names:ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member 4
Protein Family:ADP/ATP translocase
UniProt Gene Name:SLC25A4  
UniProt Entry Name:ADT1_HUMAN
Anti-SLC25A4 Antibody (CAB15027)Immunofluorescence analysis of HeLa cells using SLC25A4 antibody (CAB15027) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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