Signal Transduction Antibodies 1
Anti-SLC25A38 Antibody (CAB13218)
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- SKU:
- CAB13218
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC25A38 Antibody |
| Antibody SKU: | CAB13218 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-220 of human SLC25A38 (NP_060345.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-220 of human SLC25A38 (NP_060345.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CMSP ITVI KTRY ESGK YGYE SIYA ALRS IYHS EGHR GLFS GLTA TLLR DAPF SGIY LMFY NQTK NIVP HDQV DATL IPIT N |
| Gene ID: | 54977 |
| Uniprot: | Q96DW6 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 33kDa |
| Observed MW: | 33kDa |
| Synonyms: | SLC25A38, SIDBA2 |
| Background: | This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia. |
| UniProt Protein Function: | SLC25A3: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). Defects in SLC25A3 are a cause of mitochondrial phosphate carrier deficiency (MPCD). MPCD is a fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. Belongs to the mitochondrial carrier family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Mitochondrial; Transporter Chromosomal Location of Human Ortholog: 12q23 Cellular Component: membrane; mitochondrion; integral to plasma membrane; mitochondrial inner membrane Molecular Function:phosphate carrier activity; symporter activity; protein complex binding Biological Process: generation of precursor metabolites and energy; transport Disease: Mitochondrial Phosphate Carrier Deficiency |
| NCBI Summary: | This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia (anemia, sideroblastic, 2, pyridoxine-refractory). A related pseudogene is found on chromosome 1. [provided by RefSeq, Aug 2017] |
| UniProt Code: | Q96DW6 |
| NCBI GenInfo Identifier: | 157388925 |
| NCBI Gene ID: | 54977 |
| NCBI Accession: | NP_060345 |
| UniProt Secondary Accession: | Q96DW6,Q96DW6, |
| UniProt Related Accession: | Q96DW6 |
| Molecular Weight: | 33kDa |
| NCBI Full Name: | mitochondrial glycine transporter isoform 1 |
| NCBI Synonym Full Names: | solute carrier family 25 member 38 |
| NCBI Official Symbol: | SLC25A38 |
| NCBI Official Synonym Symbols: | SIDBA2 |
| NCBI Protein Information: | mitochondrial glycine transporter |
| UniProt Protein Name: | Phosphate carrier protein, mitochondrial |
| UniProt Synonym Protein Names: | Phosphate transport protein; PTP; Solute carrier family 25 member 3 |
| UniProt Gene Name: | SLC25A3 |
| UniProt Entry Name: | MPCP_HUMAN |
 | Western blot analysis of extracts of 293T cells, using SLC25A38 antibody (CAB13218) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of NIH/3T3 cells using SLC25A38 antibody (CAB13218) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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