Name: Anti-SLC25A31 Antibody (CAB16577)
Brand: Signal Transduction Antibodies 2
SKU: CAB16577
Availability: OutOfStock

Antibody Name:	Anti-SLC25A31 Antibody
Antibody SKU:	CAB16577
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SLC25A31 (NP_112581.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:	Mouse testis, Rat testis

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SLC25A31 (NP_112581.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	NFAF KDKY KQLF MSGV NKEK QFWR WFLA NLAS GGAA GATS LCVV YPLD FART RLGV DIGK GPEE RQFK GLGD CIMK IAKS DGIA GLYQ GFGV SVQG IIVY R
Gene ID:	83447
Uniprot:	Q9H0C2
Cellular Location:	Cell projection, Mitochondrion inner membrane, Multi-pass membrane protein, cilium, flagellum
Calculated MW:	35kDa
Observed MW:	35kDa

Synonyms:

SLC25A31, AAC4, ANT 4, ANT4, SFEC35kDa

Background:

The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt Protein Function:	SLC25A31: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility. Belongs to the mitochondrial carrier family.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter; Mitochondrial; Transporter, SLC family Chromosomal Location of Human Ortholog: 4q28.1 Cellular Component: mitochondrion; nucleus Molecular Function:structural constituent of ribosome Biological Process: translation
NCBI Summary:	The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
UniProt Code:	Q9H0C2
NCBI GenInfo Identifier:	74752557
NCBI Gene ID:	83447
NCBI Accession:	Q9H0C2.1
UniProt Related Accession:	Q9H0C2
Molecular Weight:	35,022 Da
NCBI Full Name:	ADP/ATP translocase 4
NCBI Synonym Full Names:	solute carrier family 25 member 31
NCBI Official Symbol:	SLC25A31
NCBI Official Synonym Symbols:	AAC4; ANT4; ANT 4; SFEC35kDa
NCBI Protein Information:	ADP/ATP translocase 4
UniProt Protein Name:	ADP/ATP translocase 4
UniProt Synonym Protein Names:	ADP,ATP carrier protein 4; Adenine nucleotide translocator 4; ANT 4
Protein Family:	ADP/ATP translocase
UniProt Gene Name:	SLC25A31
UniProt Entry Name:	ADT4_HUMAN

Western blot analysis of extracts of various cell lines, using SLC25A31 antibody (CAB16577) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

SLC25A31 Antibody (PACO00398)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)