Signal Transduction Antibodies 2

Anti-SLC25A26 Antibody (CAB15557)

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SKU:
CAB15557
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC25A26 Antibody
Antibody SKU:CAB15557
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 105-185 of human SLC25A26 (NP_775742.4).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse testis, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 105-185 of human SLC25A26 (NP_775742.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IRVP SEVV KQRA QVSA STRT FQIF SNIL YEEG IQGL YRGY KSTV LREI PFSL VQFP LWES LKAL WSWR QDHV VDSW QSAV C
Gene ID:115286
Uniprot:Q70HW3
Cellular Location:Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:7kDa/20kDa/29kDa
Observed MW:33kDa
Synonyms:SLC25A26, COXPD28, SAMC
Background:This gene is a member of the mitochondrial carrier family which includes nuclear-encoded transporters localized on the inner mitochondrial membranes. Members of the family transport important small molecules across the mitochondrial inner membrane. This protein is involved in the transport of S-adenosylmethionine (SAM) into the mitochondria. Mutations in this gene are associated with combined oxidative phosphorylation deficiency 28. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:SLC25A26: Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S- adenosylmethionine (SAM) into the mitochondria. Belongs to the mitochondrial carrier family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family; Mitochondrial

Chromosomal Location of Human Ortholog: 3p14.1

Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion

Molecular Function:S-adenosylmethionine transmembrane transporter activity; structural constituent of ribosome

Biological Process: S-adenosylmethionine transport; translation

NCBI Summary:Mitochondrial carriers, including SLC25A26, are a family of transport proteins found mostly in the inner membranes of mitochondria. They shuttle metabolites and cofactors through the mitochondrial membrane (Agrimi et al., 2004 [PubMed 14674884]).[supplied by OMIM, Mar 2008]
UniProt Code:Q70HW3
NCBI GenInfo Identifier:258645122
NCBI Gene ID:115286
NCBI Accession:NP_001158268.1
UniProt Secondary Accession:Q70HW3,Q7Z786, Q96E68, A8K758, B3KRZ7,
UniProt Related Accession:Q70HW3
Molecular Weight:7,405 Da
NCBI Full Name:S-adenosylmethionine mitochondrial carrier protein isoform b
NCBI Synonym Full Names:solute carrier family 25 (S-adenosylmethionine carrier), member 26
NCBI Official Symbol:SLC25A26  
NCBI Official Synonym Symbols:SAMC  
NCBI Protein Information:S-adenosylmethionine mitochondrial carrier protein
UniProt Protein Name:S-adenosylmethionine mitochondrial carrier protein
UniProt Synonym Protein Names:Mitochondrial S-adenosylmethionine transporter; Solute carrier family 25 member 26
Protein Family:S-adenosylmethionine mitochondrial carrier protein
UniProt Gene Name:SLC25A26  
UniProt Entry Name:SAMC_HUMAN
Anti-SLC25A26 Antibody (CAB15557)Western blot analysis of extracts of various cell lines, using SLC25A26 antibody (CAB15557) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90S.
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